张铧坤
东北师范大学生命科学学院
个人简历
2019年获批国家级“四青”人才项目。一直从事植(作)物多倍体演化的研究,目前重点研究方向为多倍体基因组和转录稳定性机制探究。主要研究对象为异源多倍体小麦及其亲本。主要研究手段为精细染色质三维构象解析技术, RNA二级和高级结构组,翻译组和降解组等,以及对应的基因组和后基因组生物信息分析。现主要承担国家自然科学基金面上项目,国家重点研发青年科学家项目等。目前以通讯和第一作者身份在国际期刊Nature Communication,Genome Biology,PANS,The Plant Cell,New Phytologist等发表论文20余篇,SCI他引900余次,i10-index (18)。获2020省科技进步一等奖。现为Frontiers in Plant Science的客座主编。 工作经历: 2015.08--2019.06 英国约翰英纳斯中心(John Innes Center)博士后研究员 2019.06-至今 东北师范大学特聘教授 教育经历: 2005.09-2009.07 西华师范大学 理学学士 2009.09-2015.01 东北师范大学 博士 第一/通讯作者文章: 1.Yang X, Yu H, Duncan S, Zhang Y, Cheema J, Liu H, Benjamin Miller J, Zhang J, Kwok CK, Zhang H*, Ding Y*. RNA G-quadruplex structure contributes to cold adaptation in plants. Nature Communications. 2022 Oct 20;13(1):6224. 2.Xu B, Zhu Y, Cao C, Chen H, Jin Q, Li G, Ma J, Zhao J, Zhu J, Ding Y, Fang X, Jin Y, Kwok C, Ren A, Wan Y, Wang Z, Xue Y, Zhang H*, Zhang Q, Zhou Y. Recent advances in RNA structurome. Science China Life Sciences. 2022 Apr 21. 3.Sun W#, Ding L, # Zhang H*. The potential role of RNA structure in crop molecular breeding. Front Plant Sci. 2022;13. 4.Zhang H*, Ding Y*. Novel insights into the pervasive role of RNA structure in post-transcriptional regulation of gene expression in plants. Biochem Soc Trans. 2021;49(4):1829-39. 5.Yang X, Yu H, Sun W, Ding L, Li J, Cheema J, Ramirez-Gonzalez R, Zhao X, Martin AC, Lu F, Liu B, Uauy C, Ding Y*, Zhang H*. Wheat in vivo RNA structure landscape reveals a prevalent role of RNA structure in modulating translational subgenome expression asymmetry. Genome Biol. 2021;22(1):326. 6.Morgan C#, Zhang H#, Henry CE, Franklin FCH, Bomblies K. Derived alleles of two axis proteins affect meiotic traits in autotetraploid Arabidopsis arenosa. Proc Natl Acad Sci U S A. 2020;117(16):8980-8. 7.Bian Y, Yang C, Ou X, Zhang Z, Wang B, Ma W, Gong L, Zhang H*, Liu B. Meiotic chromosome stability of a newly formed allohexaploid wheat is facilitated by selection under abiotic stress as a spandrel. New Phytol. 2018;220(1):262-77. 8.Morgan CH#, Zhang H#, Bomblies K. Are the effects of elevated temperature on meiotic recombination and thermotolerance linked via the axis and synaptonemal complex? Philos Trans R Soc Lond B Biol Sci. 2017;372(1736). 9.Zhang H#, Gou X, Zhang A, Wang X, Zhao N, Dong Y, Li L, Liu B. Transcriptome shock invokes disruption of parental expression-conserved genes in tetraploid wheat. Sci Rep. 2016;6:26363. 10.Zhang H#, Zhu B, Qi B, Gou X, Dong Y, Xu C, Zhang B, Huang W, Liu C, Wang X, Yang C, Zhou H, Kashkush K, Feldman M, Wendel JF, Liu B. Evolution of the BBAA component of bread wheat during its history at the allohexaploid level. Plant Cell. 2014;26(7):2761-76. 11.Zhang H#, Bian Y, Gou X, Zhu B, Xu C, Qi B, Li N, Rustgi S, Zhou H, Han F, Jiang J, von Wettstein D, Liu B. Persistent whole-chromosome aneuploidy is generally associated with nascent allohexaploid wheat. Proc Natl Acad Sci U S A. 2013;110(9):3447-52. 12.Zhang H, Bian Y, Gou X, Dong Y, Rustgi S, Zhang B, Xu C, Li N, Qi B, Han F, von Wettstein D, Liu B. Intrinsic karyotype stability and gene copy number variations may have laid the foundation for tetraploid wheat formation. Proc Natl Acad Sci U S A. 2013;110(48):19466-71.