个人简历

丹麦哥本哈根大学 (University of Copenhagen) 博士、博士后，现为东北师范大学分子表观遗传学教育部重点实验室教授、博士生导师，吉林省拔尖创新人才，吉林省细胞生物学会秘书长，长春市医学会转化医学专业委员会副主任委员，国际学术期刊《Epigenetics Insights》副主编。多年来致力于蛋白质翻译后修饰和染色质复制的研究，先后主持国家自然科学基金青年和面上项目、吉林省人才开发资金等项目；近五年，做为通讯作者（含共同）在 Nat Struct & Mol Biol、Proc. Natl. Acad. Sci. U S A、EMBO J、Cell Rep、eLife、J Biol Chem 等国际主流学术期刊发表论文 20 余篇，累计引用千余次。 荣获中国细胞生物学学会青年教师讲课活动二等奖、吉林省高校教师教学创新大赛二等奖、东北师范大学“卓越青年研究生导师”称号，参与建成国家级一流本科课程《分子生物学实验技术》以及中国大学慕课线上课程《细胞生物学》和《分子生物学》，主讲课程入选东北师范大学“创造的教育”示范课堂，参与首届“吉林省课程思政示范项目”，参编高等教育出版社《细胞生物学简明教程》、《细胞生物学实验指导》等教材，指导本科生获得全国大学生生命科学竞赛一等奖。 欢迎对蛋白质翻译后修饰和染色质复制感兴趣的本/硕/博同学加入我们！ 2016 - 至今，副教授、教授，东北师范大学 2014 - 2016，博士后，丹麦哥本哈根大学 2009 - 2014，理学博士，丹麦哥本哈根大学 2008 - 2009，研究助理，丹麦哥本哈根大学 2005 - 2008，理学硕士，东北师范大学 2001 - 2005，理学学士，东北师范大学 获奖情况： 2024，吉林省高校教师教学创新大赛二等奖 2024，东北师范大学“卓越青年研究生导师” 2022，中国细胞生物学学会CST青年教师讲课活动二等奖 2021，吉林省拔尖创新人才 2019，吉林省人才开发资金 2013，国家优秀留学博士奖学金 2011，最佳海报奖（TOP 1），国际会议 Frontiers in Cell Biology - 39th Annual Meeting（丹麦，赫尔辛格） 2011，最佳报告人（TOP 1），MoMeD Summer School（丹麦，哥本哈根） 教学信息： -细胞分子生物学 -分子生物学 -细胞生物学实验技术与方法 -细胞重要生命活动的调控机制-分子生物学 -高级细胞生物学（留学生） -分子生物学实验 -现代生物实验技术 科研信息： -发表文章 1. Yingying Zou#, Jiayao Pei#, Haizhen Long#, Liting Lan, Kejian Dong, Tingting Wang, Ming Li, Zhexuan Zhao, Lirun Zhu, Gangxuan Zhang, Xin Jin, Yang Wang, Zengqi Wen, Min Wei, Yunpeng Feng*. H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins. Nat Struct Mol Biol.2023; doi: 10.1038/s41594-023-00998-6. 2. Fengqi Hao#, Miaomiao Tian#, Xinbo Zhang#, Xin Jin, Ying Jiang, Xue Sun, Yang Wang, Pinghui Peng, Jia Liu, Chaoyi Xia, Yunpeng Feng*, Min Wei*. Butyrate Enhances CPT1A Activity to Promote Fatty Acid Oxidation and iTreg Differentiation. Proc. Natl. Acad. Sci. U S A. 2021;118(22):e2014681118. 3. Miaomiao Tian#, Fengqi Hao#, Xin Jin, Xue Sun, Ying Jiang, Yang Wang, Dan Li, Tianyi Chang, Yingying Zou, Pinghui Peng, Chaoyi Xia, Jia Liu, Yuanxi Li, Ping Wang, Yunpeng Feng*, Min Wei*. ACLY ubiquitination by CUL3-KLHL25 coordinates fatty acid synthesis to promote iTreg differentiation. eLife. 2021;10:e62394. 4. Xin Jin#, Wenxia Zhang#, Yang Wang, Jia Liu, Fengqi Hao, Yunlong Li, Miaomiao Tian, Hengyao Shu, Jiaxin Dong, Yunpeng Feng*, Min Wei*. PKM2 promotes the activation of dendritic cells by enhancing IL-12 p35 expression. Cell Reports. 2020; 31(8):107690. 5. Hongyu Chen, Jin Shan, Jialing Liu, Yunpeng Feng, Yueshuang Ke, Wenjing Qi, Wenguang Liu, Xianlu Zeng. RNF8 promotes efficient DSB repair by inhibiting the pro‐apoptotic activity of p53 through regulating the function of Tip60. Cell Prolif. 2020; 53(3):e12780. 6. Yang Jiao, Yunpeng Feng, Xiuli Wang. Regulation of tumor suppressor gene CDKN2A and encoded p16-INK4a protein by covalent modifications. Biochemistry (Mosc), 2018; 83(11):1289-1298. 7. Lingling Chen, Yang Jiao, Xin Guan, Xiliang Li, Yunpeng Feng, Mingda Jiao. Investigation of cell cycle-associated structural reorganization in nucleolar FC/DFCs from mouse MFC cells by electron microscopy. Microscopy. 2018; doi: 10.1093/jmicro/dfy020. 8. Fengqi Hao#, Miaomiao Tian#, Yunpeng Feng, Chao Quan, Yixi Chen, Shuai Chen, Min Wei. Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient MRL/lpr Mice. J Immunol. 2018; 200(12):3905-3912. 9. Xin Jin, Qingpan Bu, Yingying Zou, Yunpeng Feng, Min Wei. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. Glycoconj J. 2018; 35(3):287-297. 10. Yang Wang#, Jia Liu#, Xin Jin#, Dapeng Zhang, Dongxue Li, Fengqi Hao, Yunpeng Feng, Shan Gu, Fanlin Meng, Miaomiao Tian, Yi Zheng, Ling Xin, Xinbo Zhang, Xue Han, L. Aravind, and Min Wei*. O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect. Proc. Natl. Acad. Sci. U S A., 2017; 114(52):13732-13737. 11. Xin Guan, Yang Jiao, Lingling Chen, Xiliang Li, Guangbin Shang, Fengcai Wang, Yunpeng Feng, Mingda Jiao. Disruption and restoration of nucleolar FC and DFC during S phase in HeLa cells. Cell Biol Int. 2017; 41(3):258-266. 12. Yunpeng Feng#, Arsenios Vlassis#, Céline Roques#, Marie‐Eve Lalonde, Cristina González‐Aguilera, Jean‐Philippe Lambert, Sung‐Bau Lee, Xiaobei Zhao, Constance Alabert, Jens V Johansen, Eric Paquet, Xiang‐Jiao Yang, Anne‐Claude Gingras, Jacques Côté, Anja Groth. BRPF3-HBO1 complex regulates replication origin firing and histone H3K14 acetylation. EMBO J. 2016; 18;35(2):176-92. 13. Saskia Hoffmann, Stine Smedegaard, Kyosuke Nakamura, Gulnahar B. Mortuza, Markus Räschle, Alain Ibañez de Opakua, Yasuyoshi Oka, Yunpeng Feng, Francisco J. Blanco, Matthias Mann, Guillermo Montoya, Anja Groth, Simon Bekker-Jensen, Niels Mailand. TRAIP is a PCNA-associated ubiquitin ligase that protects genome stability after replication stress. J Cell Biol. 2016; 4;212(1):63-75. 14. Jakob Mejlvang#, Yunpeng Feng#, Constance Alabert, Kai J Neelsen, Zuzana Jasencakova, Xiaobei Zhao, Michael Lees, Albin Sandelin, Philippe Pasero, Massimo Lopes, Anja Groth. New histone supply regulates replication fork speed and PCNA unloading. J Cell Biol. 2014; 6;204(1):29-43. 15. Katrine Ask, Zuzana Jasencakova, Patrice Menard, Yunpeng Feng, Geneviève Almouzni, Anja Groth. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. EMBO J. 2012; 31(8):2013-23. 16. Xiuli Wang, Yunpeng Feng, Jing Zhao, Hong Pan, Baiqu Huang, Jun Lu. The expression of p16 is regulated by the reversible histone acetylation. Prog Biochem Biophys. 2010; 2010(037), 006 17. Yunpeng Feng#, Xiuli Wang#, Liang Xu, Hong Pan, Shan Zhu, Qian Liang, Baiqu Huang, Jun Lu. The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence. FEBS J. 2009; 276(15):4197-206. 18. Dongmei Su, Shan Zhu, Xuefang Han, Yunpeng Feng, Hui Huang, Guoling Ren, Lina Pan, Yu Zhang, Jun Lu, Baiqu Huang. BMP4-Smad signal pathway mediates Adriamycin-induced premature senescence in lung cancer cells. J Biol Chem. 2009; 284(18):12153-64. 19. Guoling Ren, Guocui Zhang, Zhixiong Dong, Zhiwei Liu, Lin Li, Yunpeng Feng, Dongmei Su, Yu Zhang, Baiqu Huang, Jun Lu. Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. Int J Biochem Cell Biol. 2009; 41(5):1094-101. 20. Yu Zhang, Shuyan Huang, Wei Dong, Lin Li, Yunpeng Feng, Lina Pan, Zhenkun Han, Xiuli Wang, Guoling Ren, Dongmei Su, Baiqu Huang, Jun Lu. SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Lett. 2009; 277(1):29-37. 21. Xiuli Wang#, Yunpeng Feng#, Liang Xu, Yuli Chen, Yu Zhang, Dongmei Su, Guoling Ren, Jun Lu, Baiqu Huang. YY1 restrained cell senescence through repressing the transcription of p16. BBA-MOL CELL RES. 2008; 1783(10):1876-83. 22. Xiuli Wang#, Lina Pan#, Yunpeng Feng, Yanle Wang, Qiuju Han, Liping Han, Songyan Han, Jianhua Guo, Baiqu Huang, Jun Lu. p300 plays a role in p16 (INK4a) expression and cell cycle arrest. Oncogene. 2008; 27(13):1894-904. 23. Xiuli Wang, Yunpeng Feng, Lina Pan, Yanle Wang, Xin Xu, Jun Lu, Baiqu Huang. The proximal GC-rich region of p16 (INK4a) gene promoter plays a role in its transcriptional regulation. Mol Cell Biochem 2007; 301(1-2):259-66. -科研项目： 1. 国家自然科学基金面上项目，32070758，丁酸通过上调脂肪酸氧化代谢促进iTreg细胞分化的作用和机制研究，2021-01 - 2024-12，主持。 2. 东北师范大学青年教师科研发展基金，谷氨酰胺缺乏影响肿瘤发生的机制研究，2019-2021，主持。 3. 吉林省人才开发资金，糖代谢调控因子在 DNA 复制中的作用及机制研究，2019–2020，主持。 4. 国家自然科学基金青年项目，31600645，组蛋白的O-GlcNAc糖基化修饰在DNA复制中的作用及机制研究，2017-01 - 2019-12，主持。 5. 东北师范大学青年探索培育基金，2412016KJ022，糖代谢调控因子在DNA复制中的作用及分子机制研究，2016-04 - 2017-11，主持。 6. 国家自然科学基金重大研究计划，91019011，间充质干细胞成骨分化中VDR及其靶基因参与遗传学调控机制的研究，2011-01 - 2013-12，参加。