职  称:教授
研究方向:药物筛选和干细胞研究
办公电话:0431-89165922
办公地点:东北师范大学净月校区
电子邮件:sunlg388@nenu.edu.cn

个人简历

现为东北师范大学药物基因和蛋白筛选国家工程实验室教授。多年来一直从事细胞生物学、分子生物学和免疫学的教学与科研工作。主持国家自然科学基金项目、香港科研基金委员会资助项目、吉林省科技发展规划项目、吉林省发改委及长春市科技局等各级科研项目,取得了一系列基础研究和应用研究的重要科研成果。在Journal of Cell Biology、Journal of Cell Science、Molecular and Cellular Biology等国际重要学术刊物上发表SCI论文40余篇。2011年被评为“吉林省高校新世纪科学技术优秀人才”及“东师学者”青年学术骨干,2013年获得“长春市政府特殊津贴”,“吉林省人才开发资金”及被授予“吉林省第四批拔尖创新人才第三层次人选”荣誉称号。 【学习经历】(含国外研修经历) 1989.9 – 1994.6 白求恩医科大学 临床医学系 本科生 1994.9 – 1997.6 白求恩医科大学 生物化学系 硕士研究生 1997.9 – 2000.6 白求恩医科大学 免疫学系 博士研究生 2001.7 – 2004.7 香港科技大学 生物化学系 博士后 2005.5 – 2006.4 美国Cleveland Clinic Lerner研究所 细胞生物学系 博士后 【工作简历】 1997.7 – 1999.7 白求恩医科大学基础医学院分子生物学教研室 助教 1999.7 – 2004.8 白求恩医科大学基础医学院分子生物学教研室 讲师 (吉林大学白求恩医学院分子生物学教研室) 2004.9 – 2009.8 吉林大学白求恩医学院分子生物学教研室 副教授 2009.9 – 2011.3 吉林大学白求恩医学部 教授 2011.4 – 今 东北师范大学药物基因和蛋白筛选国家工程实验室 教授 【社会学术兼职】 中国免疫学会青年工作者委员会第二届常委,吉林省免疫学会第二届理事会理事,吉林省生物治疗学会第二届理事会常务理事,吉林省康复医学会第一届健康管理专业委员会常务委员,中国细胞生物学学会、中国免疫学学会和吉林省药理学会会员,吉林省药学会第七届药理专业委员会委员。 【主要科研方向】 一、糖尿病和肿瘤治疗药物筛选模型的建立 二、糖尿病和肿瘤治疗药物筛选及作用机制研究 三、肿瘤发生的分子机制研究 四、干细胞研究 【博士及硕士研究生招生】 专业:细胞生物学 招生信息详见国家工程实验室网站:http://www.neldgps.com/rencaipeiyang/91086 【代表性论文】 1. Yucui Liu, Yanjie Xu, Qiuhang Song, Fei Wang, Luguo Sun**, Lei Liu, Xiaoguang Yang, Jingwen Yi, Yongli Bao, Haifeng Ma, Honglan Huang***, Chunlei Yu, Yanxin Huang, Yin Wu*, Yuxin Li. Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutansFront Microbiol. 2017 Sep 13;8:1738. doi: 10.3389/fmicb.2017. 01738. eCollection 2017. 2. Hui-Han Ai, Zi-Long Zhou, Lu-Guo Sun*, Mei-Ting Yang, Wei Li, Chun-Lei Yu, Zhen-Bo Song, Yan-Xin Huang, Yin Wu, Lei Liu, Xiao-Guang Yang, Yu-Qing Zhao***, Yong-Li Bao**, Yu-Xin Li. 20(S)-25-methoxyl-dammarane- 3β, 12β, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells. Apoptosis. 2017 Sep 1. doi: 10.1007/s10495-017-1416-9. [Epub ahead of print] PubMed PMID: 28864870. 3. Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun*, Yuxin Li**. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4). pii: E794. doi: 10.3390/ijms18040794 4. Yue Cao, Xiaoguang Yang, Yannan Wu, Jingwen Yi, Yin Wu, Chunlei Yu, Yanxin Huang, Yongli Bao***, Luguo Sun*, Yuxin Li**. Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model. RSC Adv. 2016(10): 111440-111446 5. Yue Cao, Yan Li, Yin Wu, Wenling Li, Chunlei Yu, Yanxin Huang, Luguo Sun*, Yongli Bao***, Yuxin Li**. Co-Delivery of angiostatin and curcumin by a biodegradable polymersome for antiangiogenic therapy. RSC Adv. 2106, 6: 105442-105448 6. Cheng Yang, Dongmei Zhang, Zhenbo Song, Yaqin Hou, Yongli Bao*, Luguo Sun**, Chunlei Yu, Yuxin Li. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e0145095. 7. Luguo Sun, Liyan Sui, Xinlin Cong, Kejuan Ma, Xiaobo Ma, Yanxin Huang, Chong Fan, Xueqi Fu, Kewei Ma*. Low incidence of IL6ST(gp130) mutations in exon6 in lung cancer of a Chinese cohort. Cancer Genet. 2014 Jul-Aug;207(7-8):291-8. doi: 10.1016/j.cancer gen.2014.07.003. Epub 2014 Aug 1. 8. Luguo Sun, Xia Cao, Bin Liu, Honglan Huang, Xu Wang, Liyan Sui, Weimin Yin, Kewei Ma*. CaMKIV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription. Cell Signal. 2011 Oct; 23(10): 1686-90. 9. Fang Xiao, Haixia Wang, Xinrong Fu, Yanfeng Li, Kewei Ma, Luguo Sun, Xiang Gao, Zhenguo Wu*. Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration. Cell Res. 2011 Feb;21(2):350-64. 10. Bohan Dong※, Luguo Sun※, Xiuli Wu, Peiyin Zhang, Li Wang, Hongfei Wei, Lei Zhou, Xiaoping Hu, Yongli Yu, Shucheng Hua*, Liying Wang*. Vaccination with TCL plus MHSP65 induces anti-lung cancer immunity in mice. Cancer Immunol Immunother. 2010 Jun; 59(6):899-908.(共第一作者) 11. Yanping Yang, Ying Xu, Wei Li, Guanjun Wang, Yanqiu Song, Guozi Yang, Xue Han, Zhonghua Du, Luguo Sun*, Kewei Ma*. STAT3 induces muscle stem cell differentiation by interaction with myoD. Cytokine. 2009 Apr;46(1):137-41. 12. Sun L, Ma K , Wang H, Xiao F, Gao Y, Zhang W, Wang K, Gao X, IP N and Wu Z. JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J. Cell Biol. 2007;179(1): 129-138 13. Sun L, Liu L, Yang XJ and Wu Z. Akt binds Prohibitin 2 and relieves its repression on MyoD and muscle differentiation. J. Cell. Sci. 2004 Jun;117:3021-9. 117: 3021-3029 14. Wan J, Sun L, Mendoza WJ, Chui YL, Huang DP, Chen XJ, Suzuki N, Suzuki S, Yeh WC, Akira S, Matsumoto K, Liu XG, and Wu Z. Elucidation of the JNK pathway mediated by Epstein-Barr virus encoded latent membrane protein 1. Mol. Cell Biol. 2004 Jan;24(1): 192-199. 15.Chan JK, Sun L, Yang XJ, Zhu G, and Wu Z. Functional characterization of an amino terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity. J. Biol. Chem. 2003 Jun; 278: 23515 – 23521.

社会兼职

获奖情况 (数据来源:科学技术处、社会科学处)

  • 2016-11-01 吉林省科学技术奖技术发明奖一等奖

教学信息

  • 天然药物与药剂学
    药物与健康
    生物技术专业实践
    生命科学导论
    分子生物学

科研信息 (数据来源:科学技术处、社会科学处)

  • 项目:
  • 1. 抗皮肤衰老日用品研发,2017年
  • 2. “和解安神汤”对肝郁脾虚型失眠大鼠的药理学研究,2016年
  • 3. 长白山道地药材为基源的II型糖尿病治疗药物筛选和临床前研究,2015年
  • 4. 抗菌型医用超声耦合剂的研制,2015年
  • 5. 医药产业比较研究与政策建议,吉林省科技厅,2013年
  • 6. 脐带间充质干细胞库关键技术及技术体系建立(吉林省人力资源和社会保障厅),吉林省人力资源和社会保障厅,2013年
  • 7. prohibitins在肿瘤细胞中生物学作用的研究,吉林省教育厅,2013年
  • 8. 中药大品种“脑心舒口服液”二次开发,吉林省科技厅,2012年
  • 9. 具有IL-6表达与功能抑制作用的中药有效成分筛选模型的建立,吉林省科技厅,2011年
  • 10. 脐带间充质干细胞库关键技术研究及技术体系建立,吉林省科技厅,2011年
  • 论文:
  • 1. Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans,FRONTIERS IN MICROBIOLOGY,2017年
  • 2. Dodartia orientalis L. essential oil exerts antibacterial activity by mechanisms of disrupting cell structure and resisting biofilm,IND CROP PROD,2017年
  • 3. 20(S)-25-methoxyl-dammarane-3b, 12b, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells,APOPTOSIS,2017年
  • 4. Efficient Cancer Regression by a Thermosensitive Liposome for Photoacoustic Imaging-Guided Photothermal/Chemo Combinatorial Therapy,BIOMACROMOLECULES,2017年
  • 5. Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling,ONCOGENE,2017年
  • 6. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo,INT J MOL SCI,2017年
  • 7. Maspin Inhibits Macrophage Phagocytosis and Enhances Inflammatory Cytokine Production via Activation of NF-kB Signaling,MOL IMMUNOL,2017年
  • 8. Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model,RSC ADVANCES,2016年
  • 9. Co-Delivery of angiostatin and curcumin by a biodegradable polymersome for antiangiogenic therapy,RSC ADVANCES,2016年
  • 10. 25-methoxyl-dammarane-3b, 12b, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation through downregulation of testes-specific protease 50(TSP50) expression,TUMOR BIOLOGY,2016年
  • 11. Virtual screening and experimental validation of novel histone deacetylase inhibitors,BMC PHARMACOLOGY & TOXICOLOGY,2016年
  • 12. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress,MOL MED REP,2016年
  • 13. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models,BIOCHEM PHARMACOL,2016年
  • 14. Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea,J ETHNOPHARMACOL,2016年
  • 15. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells,APOPTOSIS,2016年
  • 16. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation,INT J BIOCHEM CELL B,2016年
  • 17. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HCC cells,OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2016年
  • 18. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-a and IL-1b, and activation of the NF-κB signaling pathway,PLOS ONE ,2015年
  • 19. Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio,BIOSCIENCE REP,2015年
  • 20. Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression,CELL DEATH & DISEASE,2015年
  • 21. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model,COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE,2015年
  • 22. Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors,COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2014年
  • 23. The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation,CELL SIGNAL,2014年
  • 24. Three new compounds from the stem bark of Juglans mandshurica,J ASIAN NAT PROD RES,2014年
  • 25. Low incidence of IL6ST(gp130) mutations in exon 6 in lung cancer of a Chinese cohort,CANCER GENETICS,2014年
  • 26. Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression,TOXICOL LETT,2014年
  • 27. Chemical constituents from the roots of Zizyphus jujuba Mill. Var. spinosa,BIOCHEM SYST ECOL,2013年
  • 28. Secondary metabolites from the stem bark of Juglans mandshurica,BIOCHEM SYST ECOL,2013年
  • 29. Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis,THEORETICAL BIOLOGY AND MEDICAL MODELLING,2013年
  • 30. A validated high-performance liquid chromatography method with diode array detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less,J PHARMACEUT BIOMED,2013年
  • 31. Four New Alkaloids from the Fermentation Broth of Armillaria mellea,HELV CHIM ACTA,2013年
  • 32. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling,BMC BIOINFORMATICS,2013年
  • 33. A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration,J ASIAN NAT PROD RES,2013年
  • 34. Detection of EML4-ALK fusion gene in Chinese lung cancers using RT-PCR,2013ICCBES,2013年
  • 35. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database,INT J MOL SCI,2012年
  • 36. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells,EUR J PHARMACOL,2012年
  • 37. N-benzoyl-12- nitrodehydroabietylamine-7-one, a novel dehydroabietylamine derivative, induces apoptosis and inhibits proliferation in HepG2 cells,CHEM-BIOL INTERACT,2012年
  • 38. Juglanthraquinone C, a novel natural compound derived from Juglans mandshurica Maxim, induces S phase arrest and apoptosis in HepG2 cells,APOPTOSIS,2012年
  • 39. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation,PLoS ONE ,2012年
  • 40. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface,CHEMISTRY CENTRAL JOURNAL,2012年
  • 41. CaMKIV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription,CELL SIGNAL,2011年
  • 42. Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration,CELL RES,2011年
  • 43. Inhibition of a C-rich oligodeoxynucleotide on activation of immune cells in vitro and enhancement of antibody response in mice,IMMUNOLOGY,2010年
  • 44. Vaccination with TCL plus MHSP65 induces anti-lung cancer immunity in mice,CANCER IMMUNOL IMMUN,2010年
  • 45. Vaccination with B16 tumor cell lysate plus recombinant Mycobacterium tuberculosis Hsp70 induces antimelanoma effect in mice,CANCER BIOTHER RADIO,2010年
  • 46. A novel canine favored CpG oligodeoxynucleotide capable of enhancing the efficacy of an inactivated aluminum-adjuvanted rabies vaccine of dog use,VACCINE,2010年
  • 47. A human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeates negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways,CLIN IMMUNOL,2010年
  • 48. Prohibitin2调节肌细胞增强因子2转录因子活性的分子机制,吉林大学学报(医学版),2009年
  • 49. 脂多糖刺激对小鼠腹腔巨噬细胞HMGB1表达的影响,中国生物制品学杂志,2009年
  • 50. Therapeutic injection of C-class CpG ODN in draining lymph node area induces potent activation of immune cells and rejection of established breast cancer in mice,CLIN IMMUNOL,2009年
  • 51. STAT3 induces muscle stem cell differentiation by interaction with myoD,CYTOKINE,2009年
  • 52. Human microsatellite DNA mimicking oligodeoxynucleotides down-regulate TLR9-dependent and -independent activation of human immune cells,MOL IMMUNOL,2009年
  • 53. JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts,J CELL BIOL,2007年
  • 54. Akt binds Prohibitin 2 and relieves its repression on MyoD and muscle differentiation,J CELL SCI,2004年
  • 55. Elucidation of the c-Jun N-Terminal Kinase pathway mediated by Epstein-Barr virus encoded latent membrane protein 1,MOL CELL BIOL,2004年
  • 56. Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity,J BIOL CHEM,2003年
  • 57. GST-人可溶性成纤维细胞生长因子受体1融合蛋白在酵母细胞中的表达及活性测定,中国免疫学杂志,2002年
  • 58. 吉林双阳型梅花鹿sentrin/SUMO的发现,遗传,2002年
  • 59. 人内皮抑制素在酵母细胞中的表达及其促成纤维细胞有丝分裂活性,中国免疫学杂志,2000年
信息维护