2017.11 吉林省自然科学一等奖 排名第二
2017.9 中国细胞生物学学会“天能”青年教师讲课比赛  二等奖
2012.12 吉林省五一劳动奖章
2012.12 吉林省经济技术创新标兵
2012.8 首届全国青年教师教学竞赛理科组二等奖
2012.6 吉林省第一届青年教师教学基本功竞赛高校组第一名
2010 教育部高校自然科学一等奖 排名第三

参与细胞生物学 遗传学实验技术等课程的讲授。

项目：
HMGA表达失调介导的异染色质损失在儿童早老症细胞衰老中的作用及机制研究，国家自然科学基金面上项目，2018.01-2021.12

一种新的小分子去乙酰化酶抑制剂AW00178抑制乳腺癌转移的作用研究,吉林省科技厅重点科技研发项目,2020.01-2022.12

化疗药物介导的衰老微环境促进乳腺癌转移的机制,吉林省科技厅自然科学基金,2018.01-2020.12

PRMT1介导的EMT与细胞衰老在乳腺癌转移中的作用及机制研究，国家自然科学基金面上项目小额探索，2016.01-2017.12

JMJD3在肿瘤细胞衰老相关异染色质凝集形成中的作用及分子机制研究，国家自然科学基金青年基金，2012.01-2014.12

专著：
1. 分子生物学实验指导，高等教育出版社，2011年
2. 细胞生物学实验指导，高等教育出版社，2011年

论文：
Liu X, Zheng W, Zhang L, Cao Z, Cong X, Hu Q, Hou J, Jin X, Yuan Q, Lin L, Tan J, Lu J, Zhang Y＊, Zhang N＊.Arginine methylation-dependent cGAS stability promotes non-small cell lung cancer cell proliferation, Cancer Letters,2024,1:586:216707.
Kong SH, Ma L, Yuan Q, Liu X, Han Y, Xiang W, Liu DX, Zhang Y＊, Lu J＊.Inhibition of EZH2 alleviates SAHA-induced senescence-associated secretion phenotype in small cell lung cancer cells，CELL DEATH DISCOVERY，2023,5;9(1):289.
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J＊, Li Z＊, Zhang Y＊.Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1，NATURE AGING，2023,;3(2):185-201
Hu Q, Zhang N, Sui T, Li G, Wang Z, Liu M, Zhu X, Huang B, Lu J＊, Li Z＊, Zhang Y＊.Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice，EMBO J，2023,42(1):e110937
Zhang N, Shang M, Li H, Wu L, Dong M, Huang B, Lu J, Zhang Y＊.Dual Inhibition of H3K9me2 and H3K27me3 Promotes Tumor Cell Senescence without Triggering the Secretion of SASP，INT J MOL SCI，2022,23(7):3911
Duan D, Shang M, Han Y, Liu J, Liu J, Kong SH, Hou J, Huang B, Lu J, Zhang Y＊.EZH2-CCF-cGAS Axis Promotes Breast Cancer Metastasis，INT J MOL SCI，2022,23(3):1788
Liu L, Zhang X, Ding H, Liu X, Cao D, Liu Y, Liu J, Lin C, Zhang N, Wang G, Hou J, Huang B, Zhang Y＊, Lu J＊.Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS，ONCOGENE，2021,40(20):3548-3563.
Zhang N, Ji J, Zhou D, Liu X, Zhang X, Liu Y, Xiang W, Wang M, Zhang L, Wang G, Huang B, Lu J, Zhang Y＊.The Interaction of the Senescent and Adjacent Breast Cancer Cells Promotes the Metastasis of Heterogeneous Breast Cancer Cells through Notch Signaling，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，2021,;22(2):849.
Lin, C., Li, H. X., Liu, J. W., Hu, Q. Y., Zhang, S., Zhang, N., Liu, L. X., Dai, Y. J., Cao, D. H., Li, X. X., Huang, B. Q., Lu, J.＊, Zhang, Y.＊. Arginine hypomethylation-mediated proteasomal degradation of histone H4-an early biomarker of cellular senescence. Cell Death and Differentiation. 2020 Sep;27(9):2697-2709

Liu, L. X., Zhang, Y.＊, Lu, J.＊ The roles of long noncoding RNAs in breast cancer metastasis. Cell Death & Disease. 2020 Sep 14;11(9):749

Liu, J. W., Feng, J. X., Li, L. L., Lin, L. Y., Ji, J. F., Lin, C., Liu, L. X., Zhang, N., Duan, D. D., Li, Z. W., Huang, B. Q., Zhang, Y.＊, Lu, J.＊ Arginine methylation-dependent LSD1 stability promotes invasion and metastasis of breast cancer. Embo Reports.
2020 Feb 5;21(2):e48597.

Ma, J.，Zhang, L. Q.，He, Z. X.，He, X. X.，Wang, Y. J.，Jian, Y. L.，Wang, X.，Zhang, B. B.，Su, C.，Lu, J.，Huang, B. Q.，Zhang, Y.，Wang, G. Y.，Guo, W. X.，Qiu, D. L.，Mei, L.，Xiong, W. C.，Zheng, Y. W.＊，Zhu, X. J.＊ Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin. Plos Biology. 2019 Oct 10;17(10):e3000461

Li, H. Y., Su, L. P., Su, X., Liu, X., Wang, D., Li, H. M., Ba, X. Q., Zhang, Y., Lu, J., Huang, B. Q.＊, Li, X. X.＊ Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans. Redox Biology. 2019 Feb;21:101111

Su, L. P.，Li, H. Y.，Huang, C.，Zhao, T. T.，Zhang, Y. J.，Ba, X. Q.，Li, Z. W.，Zhang, Y.，Huang, B. Q.，Lu, J.＊，Zhao, Y. M.＊，Li, X. X.＊ Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression. Cell Reports. 2018 Mar 6;22(10):2716-2729

Zhang, S.，Fan, Z. B.，Qiao, P.，Zhao, Y. S.，Wang, Y. A.，Jiang, D.，Wang, X. M.，Zhu, X. J.，Zhang, Y.，Huang, B. Q.，Lu, J.＊，Li, X. X.＊ miR-51 regulates GABAergic synapses by targeting Rab GEF GLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans. Dev Biol. 2018 Apr 1;436(1):66-74.

Dong, Z. X., Yang, Y., Liu, S. X., Lu, J., Huang, B. Q., Zhang, Y.＊ HDAC inhibitor PAC-320 induces G2/M cell cycle arrest and apoptosis in human prostate cancer. Oncotarget. 2017 Dec 8;9(1):512-523.

Li, Z. W., Dong, M. C., Fan, D. M., Hou, P. F., Li, H. Y., Liu, L. X., Lin, C., Liu, J. W., Su, L. P., Wu, L., Li, X. X., Huang, B. Q., Lu, J., Zhang, Y.＊ LncRNA ANCR down-regulation promotes TGF-beta-induced EMT and metastasis in breast cancer. Oncotarget. 2017 Jun 27;8(40):67329-67343.

Geng, P. Y.，Zhang, Y.，Liu, X. Q.，Zhang, N.，Liu, Y. Q.，Liu, X.，Lin, C.，Yan, X.，Li, Z. W.，Wang, G. N.，Li, Y. X.，Tan, J.，Liu, D. X.，Huang, B. Q.＊，Lu, J.＊ Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression. FASEB Journal. 2017 Jun;31(6):2287-2300

Feng, J.，Li, L.，Zhang, N.，Liu, J.，Zhang, L.，Gao, H.，Wang, G.，Li, Y.，Zhang, Y.，Li, X.，Liu, D.，Lu, J.＊，Huang, B. Q.＊ Androgen and AR contribute to breast cancer development and metastasis: an insight of mechanisms. Oncogene. 2017;36(20):2775-2790

Li, H. Y.，Liu, X., Wang, D.，Su, L. P.，Zhao, T. T.，Li, Z. W.，Lin, C.，Zhang, Y.，Huang, B. Q.，Lu, J.＊，Li, X. X.＊ O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans. Scientific Reports. 2017 Mar 8;7:43601

Li, Z. W.，Hou, P. F.，Fan, D. M.，Dong, M. C.，Ma, M. S.，Li, H. Y.，Yao, R. S.，Li, Y. X.，Wang, G. N.，Geng, P. Y.，Mihretab, A.，Liu, D. X.，Zhang, Y.，Huang, B. Q. ＊，Lu, J. ＊ The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer. Cell Death and Differentiation.
2017 Jan;24(1):59-71.

Feng, J. X., Xu, G. Y., Liu, J. W., Zhang, N., Li, L. L., Ji, J. F., Zhang, J. C., Zhang, L., Wang, G. N., Wang, X. L., Tan, J., Huang, B. Q., Lu, J., Zhang, Y.＊ Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer. Breast Cancer Research and Treatment.  2016 Oct;159(3):443-56

Zhu, S., Zhao, L., Li, Y. Y., Hou, P. F., Yao, R. S., Tan, J., Liu, D. X., Han, L. P., Huang, B. Q., Lu, J., Zhang, Y.＊ Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. Journal of Cellular Biochemistry. 2016 Jun;117(6):1359-69. 

Liu, X., Li, H. Y., Liu, L. X., Lu, Y., Gao, Y. Y., Geng, P. Y., Li, X. X., Huang, B. Q., Zhang, Y.＊, Lu, J.＊ Methylation of arginine by PRMT1 regulates Nrf2 transcriptional activity during the antioxidative response. Biochimica Et Biophysica Acta-Molecular Cell Research. 2016 Aug;1863(8):2093-103

Gao, Y. Y., Zhao, Y. P., Zhang, J. C., Lu, Y., Liu, X., Geng, P. Y., Huang, B. Q., Zhang, Y.＊, Lu, J. ＊ The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Scientific Reports. 2016 Jan 27;6:19874

Li, L. L., Liu, D. X., Zhang, N., Liang, Q., Feng, J. X., Yao, M., Liu, J. W., Li, X. X., Zhang, Y., Lu, J., Huang, B. Q. ＊ SHON, a novel secreted protein, regulates epithelial-mesenchymal transition through transforming growth factor-beta signaling in human breast cancer cells. 2015 Mar 15;136(6):1285-95.

Zhao, L., Zhang, Y., Gao, Y., Geng, P., Lu, Y., Liu, X., Yao, R., Hou, P., Liu, D., Lu, J., Huang, B. Q.＊ JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein. Cell Death and Differentiation. 2015, 22(10):1630-1640

Shi, X., Tian, B. Q., Ma, W. L., Zhang, N., Qiao, Y. H., Li, X. X., Zhang, Y., Huang, B. Q., Lu, J.＊ A novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase 2 in primary human fibroblast cells. Bioscience Reports. 2015 Jan 14;35(1):e00169

Yao, R. S., Jiang, H., Ma, Y. H., Wang, L. P., Wang, L., Du, J., Hou, P. F., Gao, Y. Y., Zhao, L., Wang, G. N., Zhang, Y., Liu, D. X., Huang, B. Q.＊, Lu, J.＊ PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer. Cancer Research. 2014 Oct 1;74(19):5656-67.

Hou, P., Zhao, Y., Li, Z., Yao, R., Ma, M., Gao, Y., Zhao, L., Zhang, Y., Huang, B., Lu, J. ＊ LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis. Cell Death & Disease. 2014, 87(12):e1287

Liang, Q., Li, L. L., Zhang, J. C., Lei, Y., Wang, L. P., Liu, D. X., Feng, J. X., Hou, P. F., Yao, R. S., Zhang, Y., Huang, B. Q.＊, Lu, J.＊ CDK5 is essential for TGF-beta 1-induced epithelial-mesenchymal transition and breast cancer progression. Scientific Reports. 2013 Oct 14;3:2932.

Zhang, Y., Gao, Y. Y., Zhao, L., Han, L. P., Lu, Y., Hou, P. F., Shi, X., Liu, X., Tian, B. Q., Wang, X. L., Huang, B. Q. ＊, Lu, J. ＊ Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells. FEBS Journal. 2013 Sep;280(18):4625-39.

Shi, X., Tian, B. Q., Liu, L. X., Gao, Y. Y., Ma, C., Mwichie, N., Ma, W. L., Han, L. P., Huang, B. Q., Lu, J., Zhang, Y.＊ Rb Protein is Essential to the Senescence-Associated Heterochromatic Foci Formation Induced by HMGA2 in Primary WI38 Cells. Journal of Genetics and Genomics. 2013 Aug 20;40(8):391-8. 

Zhang, J. C., Lei, Y., Gao, X. G., Liang, Q., Li, L. L., Feng, J. X., Hou, P. F., Han, L. P., Zhang, Y., Huang, B. Q., Lu, J.＊ p53 Attenuates the oncogenic Ras-induced epithelial-mesenchymal transition in human mammary epithelial cells. Biochemical and Biophysical Research Communications. 2013 May 10;434(3):606-13.

Wang, X. L., Huang, Y., Zhao, J., Zhang, Y., Lu, J.＊, Huang, B. Q.＊ Suppression of PRMT6-mediated arginine methylation of p16 protein potentiates its ability to arrest A549 cell proliferation. International Journal of Biochemistry & Cell Biology. 2013 May 10;434(3):606-13.

Zhang, J. C., Liang, Q., Lei, Y., Yao, M., Li, L. L., Gao, X. G., Feng, J. X., Zhang, Y., Gao, H. W., Liu, D. X., Lu, J.＊, Huang, B. Q.＊ SOX4 Induces Epithelial-Mesenchymal Transition and Contributes to Breast Cancer Progression. Cancer Research. 2012 Sep 1;72(17):4597-608. 

Liu, Z. W., Ren, G. L., Shangguan, C. Y., Guo, L. J., Dong, Z. X., Li, Y. Y., Zhang, W. N., Zhao, L., Hou, P. F., Zhang, Y., Wang, X. L., Lu, J.＊, Huang, B. Q.＊ ATRA Inhibits the Proliferation of DU145 Prostate Cancer Cells through Reducing the Methylation Level of HOXB13 Gene. PLoS One. 2012;7(7):e40943.

Zhu, S., Li, Y. Y., Zhao, L., Hou, P. F., Shangguan, C. Y., Yao, R. S., Zhang, W. N., Zhang, Y., Tan, J., Huang, B. Q.＊, Lu, J.＊ TSA-Induced JMJD2B Downregulation Is Associated With Cyclin B1-Dependent Survivin Degradation and Apoptosis in LNCap Cells. Journal of Cellular Biochemistry. 2012 Jul;113(7):2375-82.

Zhang Y, Gao Y, Zhang G, Huang S, Dong Z, Kong C, Su D, Du J, Zhu S, Liang Q, Zhang J, Lu J, Huang B. ＊ DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. Int J Cancer. 2011 Feb 1;128(3):551-61.

Zhou, X., Huang, S. Y., Feng, J. X., Gao, Y. Y., Zhao, L., Lu, J., Huang, B. Q., Zhang, Y.＊ SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells. World Journal of Gastroenterology. 2011 Nov 28;17(44):4922-7.

Wang, X. L., Feng, Y. P., Xu, L., Chen, Y. L., Zhang, Y., Su, D. M., Ren, G. L., Lu, J.＊, Huang, B. Q. ＊ YY1 restrained cell senescence through repressing the transcription of p16. Biochim Biophys Acta. 2008 Oct;1783(10):1876-83. 

Zhang Y, Huang S, Dong W, Li L, Feng Y, Pan L, Han Z, Wang X, Ren G, Su D, Huang B, Lu J. ＊ SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Lett. 2009 May 8;277(1):29-37.

Pan, L. N., Lu, J., Wang, X. L., Han, L. P., Zhang, Y., Han, S. Y., Huang, B. Q.＊ Histone deacetylase inhibitor trichostatin A potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. Cancer. 2007 Apr 15;109(8):1676-88. 

Han, S., Lu, J., Zhang, Y., Cheng, C., Li, L., Han, L. P., Huang, B. Q.＊ HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter region. Immunology Letters. 2007 Feb 15;108(2):143-50.

Han, S. Y., Lu, J., Zhang, Y., Cheng, C., Han, L. P., Wang, X. L., Li, L., Liu, C. Y., Huang, B. Q. ＊ Recruitment of histone deacetylase 4 by transcription factors represses interieukin-5 transcription. Biochemical Journal. 2006 Dec 15;400(3):439-48.

专利：
蛋白质精氨酸甲基转移酶7在癌细胞转移中的应用 2017-01-04