职  称:教授
研究方向:生物信息学
办公电话:QQ:2584818528
办公地点:东北师范大学净月校区
电子邮件:huangyx356@nenu.edu.cn

个人简历

东北师范大学生命科学学院教授、博士生导师。1989年本科毕业于北京理工大学应用数学专业,计算机应用技术专业硕士、博士,细胞生物学专业博士后。目前主要从事生物信息学和系统生物学的理论和应用研究,主要研究内容包括抗肿瘤和抗糖尿病药物分子计算机辅助筛选和实验验证,以及基于组学技术和计算系统生物学分析的药物分子作用机制研究。承担本科生《生物信息学》课程的教学工作。承担完成国家、省部和市级科研项目十余项。在国际、国内重要学术期刊发表论文40余篇,获省部级科技进步一等奖一项。 主要学习简历 1985.9-1989.7 北京理工大学应用数学系应用数学专业 本科生 1996.9-1999.3 长春理工大学计算机学院计算机应用专业 硕士研究生 2001.9-2004.12 吉林大学计算机科学与技术学院计算机应用技术专业 博士研究生 2006.12-2008.12 东北师范大学遗传与细胞研究所 博士后 主要工作简历 1989.7-1996.8 长春第一汽车制造厂 助理工程师 1993.3-1994.5 日本共和电脑株式会社、日本富士通株式会社 工作、研修 1999.3-2006.9 吉林大学计算机科学与技术学院 讲师 2006.9-2009.4 吉林大学计算机科学与技术学院 副教授 2009.4-2013.12 东北师范大学生命科学学院 药物基因和蛋白筛选国家工程实验室 副教授、博士生导师 2013.12至今 东北师范大学生命科学学院 药物基因和蛋白筛选国家工程实验室 教授、博士生导师 主要科研方向 (1)生物信息学与系统生物学 (2)计算机辅助药物分子筛选 博士及硕士研究生招生 专业:细胞生物学 招生信息详见国家工程实验室网站:http://www.neldgps.com/rencaipeiyang/91086 主要论文成果 [1]Fan C, Huang Y*. Identification of novel potential scaffold for class I HDACs inhibition: An in-silico protocol based on virtual screening, molecular dynamics, mathematical analysis and machine learning. Biochem Biophys Res Commun. 2017 Sep 23; 491(3): 800-806. [2]Huang YX*, Zhao J, Song QH, Zheng LH, Fan C, Liu TT, Bao YL, Sun LG, Zhang LB*, Li YX*. Virtual screening and experimental validation of novel histone deacetylase inhibitors. BMC Pharmacol Toxicol. 2016 Jul 21; 17(1): 32. [3]Wang HY, Huang YX*, Zheng LH, Bao YL, Sun LG, Wu Y, Yu CL, Song ZB, Sun Y, Wang GN, Ma ZQ, Li YX*. Modelling coupled oscillations in the Notch, Wnt, and FGF signaling pathways during somitogenesis: acomprehensive mathematical model. Comput Intell Neurosci. 2015;2015:387409. [4]Qi YF, Huang YX*, Dong Y, Zheng LH, Bao YL, Sun LG, Wu Y, Yu CL, Jiang HY, Li YX*. Systematic analysis of time-series gene expression data on tumor cell-selective apoptotic responses to HDACinhibitors. Comput Math Methods Med. 2014;2014:867289. [5]Wang HY, Huang YX*, Qi YF, Zhang Y, Bao YL, Sun LG, Zheng LH, Zhang YW, Ma ZQ*, Li YX*. Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis. Theor Biol Med Model. 2013; 10(1): 27. [6]YF Qi, YX Huang*, HY Wang, Y Zhang, YL Bao, LG Sun, Y Wu, CL Yu, ZB Song, LH Zheng, Y Sun, GN Wang, YX Li*. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling. BMC Bioinformatics. 2013, 14(1): 41. [7]J Huang*, Ratmir Derda, YX Huang. Phage Display Informatics. Comput Math Method M. vol 2013, pp: 698395. [8]C Fan, YX Huang*, YL Bao*, LG Sun, Y Wu, CL Yu, Y Zhang, ZB Song, LH Zheng, Y Sun, GN Wang, YX Li*. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database. INT J MOL SCI. 2012, 13(12), 17185-17209. [9]YX Sun, YX Huang*, FL Li, HY Wang, C Fan, YL Bao, LG Sun, ZQ Ma, J Kong*, YX Li*. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface. CHEM CENT J. 2012, 6:2. [10]WH Chen, WW Guo, YX Huang*, ZQ Ma*. PepMapper: A Collaborative Web Tool for Mapping Epitopes from Affinity-Selected Peptides. PLoS ONE 2012, 7(5): e37869. [11]XW Zhao, JK Li, YX Huang*, ZQ Ma*, MH Yin*. Prediction of Bioluminescent Proteins Using Auto Covariance Transformation of Evolutional Profiles. INT J MOL SCI. 2012, 13(3), 3650-3660. [12]ZL Cao, JZ Meng, XX Li, RP Wu, YX Huang, YX He*. The Epitope and Neutralization Mechanism of AVFluIgG01, a Broad-Reactive Human Monoclonal Antibody against H5N1 Influenza Virus. PLoS ONE 2012, 7(5): e38126. [13]M Zheng, JN Wu, YX Huang, GX Liu, Y Zhou*, CG Zhou. Inferring Gene Regulatory Networks by Singular Value Decomposition and Gravitation Field Algorithm. PLoS ONE 2012, 7(12): e51141. [14]M Zheng, YX Huang, W Shen, Y Zhong, JN Wu, GX Liu*, Y Zhou*. A novel scale-free network construction method and its application in gene expression profiles simulation. PROG BIOCHEM BIOPHYS. 2012, 39(6): 581-590. [15]PP Sun, WH Chen, YX Huang*, HY Wang, ZQ Ma*, YH Lv*. Epitope prediction based on random peptide library screening: Benchmark datasets and prediction tools evaluation. Molecules 2011; 16(6): 4971-4993. [16]WH Chen, PP Sun, Y Lu, WW Guo, YX Huang*, ZQ Ma*. MimoPro. a more efficient Web-based tool for epitope prediction using phage display libraries. BMC Bioinformatics 2011; 12: 199. [17]YX Huang, YL Bao*, SY Guo, Y Wang, CG Zhou, YX Li*. Pep-3D-Search: a method for B-cell epitope prediction based on mimotope analysis. BMC Bioinformatics, 2008, 9:538. [18]黄艳新, 鲍永利*, 李玉新*. 抗原表位预测的免疫信息学方法研究进展. 中国免疫学杂志, 2008, Vol 24, No 9, pp 857-861.

社会兼职

获奖情况 (数据来源:科学技术处、社会科学处)

  • 2016-11-01 吉林省科学技术奖技术发明奖一等奖
  • 2014-09-01 吉林省自然科学学术成果奖二等奖

教学信息 (数据来源:教务处)

  • 生命科学导论
  • 生物技术专业实践3
  • 生物信息学
  • 生物技术专业实践
  • 技术专业见习

科研信息 (数据来源:科学技术处、社会科学处)

  • 项目:
  • 1. 药物计算与实验筛选产学研联盟科技创新攻关平台,长春市科技局,2014年
  • 2. 通过基因芯片数据分析与系统生物学建模方法识别诱导癌细胞凋亡药物靶标,吉林省科技厅,2013年
  • 3. 基于药效团和定量构效关系模型的计算机虚拟筛选平台,吉林省中医药管理局,2012年
  • 4. 细胞凋亡信号转导网络多尺度建模及其在新抗肿瘤药物靶标识别方面的应用研究,国家自然科学基金委员会,2011年
  • 5. 中药有效成分和药物分子作用靶标的计算机虚拟筛选,吉林省中医药管理局,2011年
  • 6. 细胞凋亡信号转导网络的计算建模研究,吉林省科技厅,2010年
  • 论文:
  • 1. Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans,FRONTIERS IN MICROBIOLOGY,2017年
  • 2. Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling,ONCOGENE,2017年
  • 3. Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model,RSC ADVANCES,2016年
  • 4. Co-Delivery of angiostatin and curcumin by a biodegradable polymersome for antiangiogenic therapy,RSC ADVANCES,2016年
  • 5. Virtual screening and experimental validation of novel histone deacetylase inhibitors,BMC PHARMACOLOGY & TOXICOLOGY,2016年
  • 6. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models,BIOCHEM PHARMACOL,2016年
  • 7. Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea,J ETHNOPHARMACOL,2016年
  • 8. A novel conformational B-cell epitope prediction method based on mimotope and patch analysis,J THEOR BIOL,2016年
  • 9. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HCC cells,OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2016年
  • 10. Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio,BIOSCIENCE REP,2015年
  • 11. Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression,CELL DEATH & DISEASE,2015年
  • 12. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model,COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE,2015年
  • 13. Conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis,BIOMED RESEARCH INTERNATIONAL,2015年
  • 14. Parthenolide-induced apoptosis, autophagy and suppression of proliferation in HepG2 cells,ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014年
  • 15. Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors,COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2014年
  • 16. The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation,CELL SIGNAL,2014年
  • 17. Three new compounds from the stem bark of Juglans mandshurica,J ASIAN NAT PROD RES,2014年
  • 18. Low incidence of IL6ST(gp130) mutations in exon 6 in lung cancer of a Chinese cohort,CANCER GENETICS,2014年
  • 19. Chemical constituents from the roots of Zizyphus jujuba Mill. Var. spinosa,BIOCHEM SYST ECOL,2013年
  • 20. Secondary metabolites from the stem bark of Juglans mandshurica,BIOCHEM SYST ECOL,2013年
  • 21. Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway,MOL MED REP,2013年
  • 22. Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction,COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2013年
  • 23. Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis,THEORETICAL BIOLOGY AND MEDICAL MODELLING,2013年
  • 24. 车载定位与防盗系统设计与实现,信息技术,2013年
  • 25. A validated high-performance liquid chromatography method with diode array detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less,J PHARMACEUT BIOMED,2013年
  • 26. Four New Alkaloids from the Fermentation Broth of Armillaria mellea,HELV CHIM ACTA,2013年
  • 27. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling,BMC BIOINFORMATICS,2013年
  • 28. A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration,J ASIAN NAT PROD RES,2013年
  • 29. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database,INT J MOL SCI,2012年
  • 30. Inferring Gene Regulatory Networks by Singular Value Decomposition and Gravitation Field Algorithm,PLoS ONE ,2012年
  • 31. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells,EUR J PHARMACOL,2012年
  • 32. A new triterpenoid and other constituents from the stem bark of Juglans mandshurica,BIOCHEM SYST ECOL,2012年
  • 33. A novel scale-free network construction method and its application in gene expression profiles simulation,PROG BIOCHEM BIOPHYS,2012年
  • 34. The Epitope and Neutralization Mechanism of AVFluIgG01, a Broad-Reactive Human Monoclonal Antibody against H5N1 Influenza Virus,PLoS ONE ,2012年
  • 35. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation,PLoS ONE ,2012年
  • 36. PepMapper: A Collaborative Web Tool for Mapping Epitopes from Affinity-Selected Peptides,PLoS ONE ,2012年
  • 37. Prediction of Bioluminescent Proteins Using Auto Covariance Transformation of Evolutional Profiles,INT J MOL SCI,2012年
  • 38. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface,CHEMISTRY CENTRAL JOURNAL,2012年
  • 39. Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshurica Maxim,HELV CHIM ACTA,2011年
  • 40. Epitope Prediction Based on Random Peptide Library Screening:Benchmark Dataset and Prediction Tools Evaluation,MOLECULES,2011年
  • 41. Testes-specific protease 50(TSP50) promotes cell proliferation through the activation of the nuclear factor κB(NF-κB) signalling pathway,BIOCHEM J,2011年
  • 42. Alantolactone Inhibits Cell Proliferation by Interrupting the Interaction between Cripto-1 and Activin Receptor Type II A in Activin Signaling Pathway,J BIOMOL SCREEN,2011年
  • 43. MimoPro: a more efficient Web-based tool for epitope prediction using phage display libraries,BMC BIOINFORMATICS,2011年
  • 44. Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells,INT J BIOCHEM CELL B,2010年
  • 45. Knockdown of TSP50 inhibits cell proliferation and induces apoptosis in P19 cells,IUBMB LIFE,2010年
  • 46. 碱性纤维母细胞生长因子通过ERK/Sp1途径下调肿瘤相关抗原TSP50的表达,第七届全国免疫学学术大会论文摘要集,2010年
  • 47. 激活素A通过Smad3信号通路诱导结肠癌细胞中SLC5A8的表达,第七届全国免疫学学术大会论文摘要集,2010年
  • 48. TSP50抗体制备及其与乳腺癌相关性的研究,第七届全国免疫学学术大会论文摘要集,2010年
  • 49. Activin A induces SLC5A8 expression through Smad3 signaling pathway in human colon cancer RKO cells,中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议论文摘要集,2010年
  • 50. Knockdown of TSP50-inhibits cell proliferation and induces apoptosis in P19 cells,中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议论文摘要集,2010年
  • 51. Alantolactone activates activin signaling pathway by disrupting the interaction of cripto-1 with activin receptor type IIA and inhibits cell proliferation,中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议论文摘要集,2010年
  • 52. Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway human colon cancer RKO cells,CHEM-BIOL INTERACT,2010年
  • 53. Down-regulation of TSP50 Expression Inhibits Cell Proliferation, Migration and Induces Cell Apoptosis in p19 Cells,第三届细胞结构与功能的信号基础研讨会,2010年
  • 54. Basci FGF Downregulates TSP50 Expression Via the ERK/Sp1 Pathway,J CELL BIOCHEM,2010年
  • 55. Pep-3D-Search:a method for B-cell epitope prediction based on mimotope analysis,BMC Bioinformatics,2008年
  • 56. 抗原表位预测的免疫信息学方法研究进展,中国免疫学杂志,2008年
  • 57. 一种基于支持向量机的蛋白质结构域边界预测方法,吉林大学学报(理学版),2008年
  • 58. A Hybrid Algorithm for Solving Generalized Class Cover Problem,LECT NOTES COMPUT SC,2006年
  • 专利:
  • B细胞抗原表位预测软件Pep-3D-Search V1.0 2011-10-26
信息维护