黄艳新

项目：
1. 组蛋白去乙酰化酶抑制剂的系统生物学研究，省、市、自治区科技项目，2022年
2. 组蛋白去乙酰化酶抑制剂对胰岛β细胞的作用及其分子机制的生物信息学研究，省、市、自治区科技项目，2018年
3. 干细胞基因组与转录组的系统生物学研发，企事业单位委托科技项目，2017年
4. 药物计算与实验筛选产学研联盟科技创新攻关平台，省、市、自治区科技项目，2014年
5. 通过基因芯片数据分析与系统生物学建模方法识别诱导癌细胞凋亡药物靶标，省、市、自治区科技项目，2013年
6. 基于药效团和定量构效关系模型的计算机虚拟筛选平台，省、市、自治区科技项目，2012年
7. 细胞凋亡信号转导网络多尺度建模及其在新抗肿瘤药物靶标识别方面的应用研究，国家自然科学基金项目，2011年
8. 中药有效成分和药物分子作用靶标的计算机虚拟筛选，企事业单位委托科技项目，2011年
9. 细胞凋亡信号转导网络的计算建模研究，省、市、自治区科技项目，2010年
论文：
1. TSP50 Attenuates DSS-Induced Colitis by Regulating TGF-β Signaling Mediated Maintenance of Intestinal Mucosal Barrier Integrity，ADVANCED SCIENCE，2024年
2. Transcriptome sequencing identifies prognostic genes involved in gastric adenocarcinoma，MOLECULAR AND CELLULAR BIOCHEMISTRY，2023年
3. Tectorigenin targets PKACalpha to promote GLUT4 expression in skeletal muscle and improve insulin resistance in vitro and in vivo，INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES，2023年
4. Matrine alleviates depressive-like behaviors via modulating microbiota-gut-brain axis in CUMS-induced mice，J TRANSL MED，2023年
5. STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression，INT J MOL SCI，2023年
6. FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion，CELL DEATH & DISEASE，2023年
7. KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3，INT J MOL SCI，2022年
8. Discovery of Phenolic Glycoside from Hyssopus cuspidatus Attenuates LPS-Induced Inflammatory Responses by Inhibition of iNOS and COX-2 Expression through Suppression of NF-κB Activation，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，2021年
9. Two new phenolic acids and one new phenolic glycoside from Hyssopus cuspidatus Boriss and their anti-inflammatory activities，PHYTOCHEMISTRY LETTERS，2021年
10. Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation，FRONTIERS IN MICROBIOLOGY，2021年
11. Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro，INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES，2021年
12. AGTAR: A novel approach for transcriptome assembly and abundance estimation using an adapted genetic algorithm from RNA-seq data，COMPUTERS IN BIOLOGY AND MEDICINE，2021年
13. Discovery and Verification of Key Liver Cancer Genes and Alternative Splicing Events Based on Second-Generation Sequencing Data Analysis，BIOL PHARM BULL，2021年
14. Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota，FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY，2021年
15. Stevioside Activates AMPK to Suppress Inflammation in Macrophages and Protects Mice from LPS-Induced Lethal Shock，MOLECULES，2021年
16. Tectorigenin enhances PDX1 expression and protects pancreatic b-cells by activating ERK and reducing ER stress，JOURNAL OF BIOLOGICAL CHEMISTRY，2020年
17. Fas and GIT1 signalling in the prefrontal cortex mediate behavioural sensitization to methamphetamine in mice，BRAIN RES BULL，2020年
18. Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo，PHARMACOL RES，2020年
19. Induced Expression of VEGFC, ANGPT, and EFNB2 and Their Receptors Characterizes Neovascularization in Proliferative Diabetic Retinopathy，INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE，2019年
20. Dracorhodin perchlorate protects pancreatic b-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo，FEBS J，2019年
21. An improved protocol for the virtual screening discovery of novel histone deacetylase inhibitors，CHEM PHARM BULL，2019年
22. Hypericin maintians PDX1 expression via the Erk pathway and protects islet b-cells against glucotoxicity and lipotoxicity，INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES，2019年
23. A novel benzamine lead compound of histone deacetylase inhibitor ZINC24469384 can suppresses HepG2 cells proliferation by upregulating NR1H4，SCIENTIFIC REPORTS，2019年
24. Chemical Composition and Antibacterial Activity of Kaempferia galanga Essential Oil，INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY，2018年
25. Prohibitin 2 localizes in nucleolus to regulate ribosomal RNA transcription and facilitate cell proliferation in RD cells，SCIENTIFIC REPORTS，2018年
26. Antibacterial Activity and Action Mechanism of the Echinops ritro L. Essential Oil Against Foodborne Pathogenic Bacteria，JOURNAL OF ESSENTIAL OIL BEARING PLANTS，2017年
27. Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans，FRONTIERS IN MICROBIOLOGY，2017年
28. Dodartia orientalis L. essential oil exerts antibacterial activity by mechanisms of disrupting cell structure and resisting biofilm，IND CROP PROD，2017年
29. 20(S)-25-methoxyl-dammarane-3b, 12b, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells，APOPTOSIS，2017年
30. Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy，JOURNAL OF MATERIALS CHEMISTRY B，2017年
31. Identification of novel potential scaffold for class I HDACs inhibition: An in-silico protocol based on virtual screening, molecular dynamics, mathematical analysis and machine learning，BIOCHEM BIOPH RES CO，2017年
32. Efficient Cancer Regression by a Thermosensitive Liposome for Photoacoustic Imaging-Guided Photothermal/Chemo Combinatorial Therapy，BIOMACROMOLECULES，2017年
33. Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling，ONCOGENE，2017年
34. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo，INT J MOL SCI，2017年
35. Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model，RSC ADVANCES，2016年
36. Co-Delivery of angiostatin and curcumin by a biodegradable polymersome for antiangiogenic therapy，RSC ADVANCES，2016年
37. A New Flavonoid Glycoside from Dodartia orientalis and Antitumor Activity Evaluation of Its Constituents，CHEMISTRY OF NATURAL COMPOUNDS，2016年
38. Virtual screening and experimental validation of novel histone deacetylase inhibitors，BMC PHARMACOLOGY & TOXICOLOGY，2016年
39. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models，BIOCHEM PHARMACOL，2016年
40. Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea，J ETHNOPHARMACOL，2016年
41. A novel conformational B-cell epitope prediction method based on mimotope and patch analysis，J THEOR BIOL，2016年
42. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HCC cells，OXIDATIVE MEDICINE AND CELLULAR LONGEVITY，2016年
43. Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio，BIOSCIENCE REP，2015年
44. Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression，CELL DEATH & DISEASE，2015年
45. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model，COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE，2015年
46. Conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis，BIOMED RESEARCH INTERNATIONAL，2015年
47. Parthenolide-induced apoptosis, autophagy and suppression of proliferation in HepG2 cells，ASIAN PACIFIC JOURNAL OF CANCER PREVENTION，2014年
48. Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors，COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE，2014年
49. The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation，CELL SIGNAL，2014年
50. Three new compounds from the stem bark of Juglans mandshurica，J ASIAN NAT PROD RES，2014年
51. Low incidence of IL6ST(gp130) mutations in exon 6 in lung cancer of a Chinese cohort，CANCER GENETICS，2014年
52. Chemical constituents from the roots of Zizyphus jujuba Mill. Var. spinosa，BIOCHEM SYST ECOL，2013年
53. Secondary metabolites from the stem bark of Juglans mandshurica，BIOCHEM SYST ECOL，2013年
54. Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway，MOL MED REP，2013年
55. Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction，COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE，2013年
56. Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis，THEORETICAL BIOLOGY AND MEDICAL MODELLING，2013年
57. 车载定位与防盗系统设计与实现，信息技术，2013年
58. A validated high-performance liquid chromatography method with diode array detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less，J PHARMACEUT BIOMED，2013年
59. Four New Alkaloids from the Fermentation Broth of Armillaria mellea，HELV CHIM ACTA，2013年
60. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling，BMC BIOINFORMATICS，2013年
61. A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration，J ASIAN NAT PROD RES，2013年
62. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database，INT J MOL SCI，2012年
63. Inferring Gene Regulatory Networks by Singular Value Decomposition and Gravitation Field Algorithm，PLoS ONE ，2012年
64. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells，EUR J PHARMACOL，2012年
65. A new triterpenoid and other constituents from the stem bark of Juglans mandshurica，BIOCHEM SYST ECOL，2012年
66. A novel scale-free network construction method and its application in gene expression profiles simulation，PROG BIOCHEM BIOPHYS，2012年
67. The Epitope and Neutralization Mechanism of AVFluIgG01, a Broad-Reactive Human Monoclonal Antibody against H5N1 Influenza Virus，PLoS ONE ，2012年
68. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation，PLoS ONE ，2012年
69. PepMapper: A Collaborative Web Tool for Mapping Epitopes from Affinity-Selected Peptides，PLoS ONE ，2012年
70. Prediction of Bioluminescent Proteins Using Auto Covariance Transformation of Evolutional Profiles，INT J MOL SCI，2012年
71. IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface，CHEMISTRY CENTRAL JOURNAL，2012年
72. Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshurica Maxim，HELV CHIM ACTA，2011年
73. Epitope Prediction Based on Random Peptide Library Screening：Benchmark Dataset and Prediction Tools Evaluation，MOLECULES，2011年
74. Testes-specific protease 50(TSP50) promotes cell proliferation through the activation of the nuclear factor κB(NF-κB) signalling pathway，BIOCHEM J，2011年
75. Alantolactone Inhibits Cell Proliferation by Interrupting the Interaction between Cripto-1 and Activin Receptor Type II A in Activin Signaling Pathway，J BIOMOL SCREEN，2011年
76. MimoPro: a more efficient Web-based tool for epitope prediction using phage display libraries，BMC BIOINFORMATICS，2011年
77. Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells，INT J BIOCHEM CELL B，2010年
78. Knockdown of TSP50 inhibits cell proliferation and induces apoptosis in P19 cells，IUBMB LIFE，2010年
79. 碱性纤维母细胞生长因子通过ERK/Sp1途径下调肿瘤相关抗原TSP50的表达，第七届全国免疫学学术大会论文摘要集，2010年
80. 激活素A通过Smad3信号通路诱导结肠癌细胞中SLC5A8的表达，第七届全国免疫学学术大会论文摘要集，2010年
81. TSP50抗体制备及其与乳腺癌相关性的研究，第七届全国免疫学学术大会论文摘要集，2010年
82. Activin A induces SLC5A8 expression through Smad3 signaling pathway in human colon cancer RKO cells，中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议论文摘要集，2010年
83. Knockdown of TSP50-inhibits cell proliferation and induces apoptosis in P19 cells，中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议论文摘要集，2010年
84. Alantolactone activates activin signaling pathway by disrupting the interaction of cripto-1 with activin receptor type IIA and inhibits cell proliferation，中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议论文摘要集，2010年
85. Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway human colon cancer RKO cells，CHEM-BIOL INTERACT，2010年
86. Down-regulation of TSP50 Expression Inhibits Cell Proliferation, Migration and Induces Cell Apoptosis in p19 Cells，第三届细胞结构与功能的信号基础研讨会，2010年
87. Basci FGF Downregulates TSP50 Expression Via the ERK/Sp1 Pathway，J CELL BIOCHEM，2010年
88. Pep-3D-Search:a method for B-cell epitope prediction based on mimotope analysis，BMC Bioinformatics，2008年
89. 抗原表位预测的免疫信息学方法研究进展，中国免疫学杂志，2008年
90. 一种基于支持向量机的蛋白质结构域边界预测方法，吉林大学学报（理学版），2008年
91. A Hybrid Algorithm for Solving Generalized Class Cover Problem，LECT NOTES COMPUT SC，2006年