职  称:教授
研究方向:基因工程药物、现代中药和干细胞制剂的研究与开发
办公电话:89165917,89165919
办公地点:国家工程实验室318室
电子邮件:liyx486@nenu.edu.cn

个人简历

留学于美国加州大学,1998年回国任东北师范大学遗传与细胞研究所副所长,教授、博士生导师。2002年起担任国家教育部农业与医药基因工程研究中心主任。2008年至今任药物基因和蛋白筛选国家工程实验室主任,兼任《中国免疫学杂志》和《中国生物制品学杂志》编委、国家知识产权战略专家、国家重点新产品计划专家、国家生物产业(长春)基地首席专家等职。 多年来主要从事基因工程制药、现代中药、干细胞技术与产品开发研究。曾承担完成国家重点基础研究发展规划(“973”)项目、国家“十五”重大科技专项项目、国家重大新药创制重大科技专项项目、国家支撑计划项目、吉林省科技发展规划重大项目等50项重要科研项目,取得了一系列基础研究和应用研究的重要科研成果。在国内外重要学术刊物发表论文200余篇。申报发明专利30余项。获省部级以上科技成果奖8项。已培养硕士、博士研究生和博士后120余人。 一直致力于生物医药产业的创新与发展。作为国家生物产业(长春)基地首席专家、吉林省决策咨询委员会委员和吉林省发展战略促进会专家,积极协助和配合政府各级主管部门开展生物产业战略研究、制定发展规划,在促进省市生物产业发展方面发挥了重要作用。创建了国家生物产业基地公共实验中心、药物基因和蛋白筛选国家工程实验室、国家人类干细胞库国际联合研究中心等一系列生物医药创新平台,主持开展了与和记黄埔集团、中生集团、修正药业集团、哈药集团、深圳益田集团、吉林省太阳鸟再生医学工程有限责任公司、长生生物科技股份有限公司等大中型企业的合作科技开发工作。创建了基因工程药物、现代中药、干细胞制剂和新型医疗器械等一系列生物医药产品开发技术体系,使多项医药科研成果通过这些体系得以转化。 主要学习简历 1979.9 — 1984.8 白求恩医科大学医学系本科生,获医学学士学位 1987.9 — 1990.8 白求恩医科大学病理学专业硕士研究生,获病理学硕士学位 1990.9 — 1993.8 白求恩医科大学免疫学专业博士研究生,获免疫学博士学位 1993.9 — 1995.9 东北师范大学遗传与细胞研究所博士后 1996.10 — 1998.8 美国加州大学旧金山医学院博士后 主要工作简历 1984.9 — 1987.8 白求恩医科大学基础医学院,助教 1995.10 — 1996.10 东北师范大学遗传与细胞研究所,教授 1998.8 — 2013.12 东北师范大学遗传与细胞研究所,副所长、教授、博士生导师 2002.3 — 至今 教育部农业与医药基因工程研究中心,主任,教授、博士生导师 2008.6 — 至今 药物基因和蛋白筛选国家工程实验室,主任,教授、博士生导师 主要研究方向或领域 目前主要研究方向为基因工程药物、现代中药和干细胞制剂的研究与开发。 (一)基础研究方面 1.系列血管生成抑制因子结构与功能相关性研究; 2.肿瘤标志分子在肿瘤发生发展中的作用研究; 3.中药化学成分生物学活性及其在人体内代谢特点的研究; 4.干细胞增殖与表达调控。 (二)应用研究方面 1.基因工程新药的研制与开发; 2.现代中药新药研制与开发; 3.干细胞制剂的研制与开发; 4.新型医用生物材料研制与开发。 主要学术兼职 中国免疫学杂志编委,中国生物制品杂志编委,中国中医药年鉴编委;中国药学会生物技术药物委员会委员,中国医药商会专家委员会委员;国家知识产权战略专家,国家新产品计划专家,国家生物产业(长春)基地首席专家。 教学工作 1.讲授课程名称、课程类别及授课对象 主要参与了现代生物技术进展、生物技术实践、基因工程技术、免疫学进展等课程的讲授。 2.博士及硕士研究生招生 硕士:遗传学 博士:细胞生物学 招生信息详见国家工程实验室网站:http://www.neldgps.com/rencaipeiyang 取得的主要科研教学成果(2013年至今) 1.学术论文 Yucui Liu, Yanjie Xu, Qiuhang Song, Fei Wang, Luguo Sun**, Lei Liu, Xiaoguang Yang, Jingwen Yi, Yongli Bao, Haifeng Ma, Honglan Huang***. Chunlei Yu,Yanxin Huang, Yin Wu* and Yuxin Li. Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans. Frontiers in Microbiology.2017,8, doi: 10.3389/fmicb.2017.01738 Z-B Song, P Wu, J-S Ni, T Liu, C Fan, Y-L Bao*, Y Wu, L-G Sun, C-L Yu,Y-X Huang and Y-X Li**. Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene, 2017,doi:10.1038/onc.2017.198.通讯作者 Yan Li , Yannan Wu , Xinlei Yao, Fang Hao , Chunlei Yu , Yongli Bao , Yin Wu , Zhenbo Song, Ying Sun , Lihua Zheng , Guannan Wang , Yanxin Huang , Luguo Sun* , and.Yuxin Li*.Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo.Int. J. Mol. Sci. 2017, 18, 794,doi:10.3390/ ijms18040794通讯作者 Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao* , Yuxin Li**.Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling. Molecular Immunology. 2017,82: Pages 94–103通讯作者 Yuwei Zhang, Hua Lin,Shanshan Li,Jianbo Chen,Yinshi Sun,Yuxin Li*. High-speed counter-current chromatography assisted preparative isolation of bioactive compounds from stem bark of Juglans mandshurica.J Sep Sci. 2017 Feb;40(3):767-778,通讯作者 Zhang WJ, Song ZB, Bao YL*, Li WL, Yang XG, Wang Q, Yu CL, Sun LG, Huang YX and Li YX*. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016, 105:66-79. 通讯作者 Mi XG, Song ZB, Sun LG, Bao YL**, Yu CL, Wu Y*, Li YX. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. Int J Biochem Cell Biol. 2016 ,73: 63–71. Hou YQ, Yao Y, Bao YL*, Song ZB*, Yang C, Gao XL, Zhang WJ, Sun LG, Yu CL, Huang YX,Wang GN, Li YX. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HepG2 cells. Oxid Med Cell Longev. 2016:4941623. Gao XL, Lin H, Zhao W, Hou YQ, Bao YL*, Song ZB, Sun LG, Tian SY, Liu B*, Li YX. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. Apoptosis. 2016,21(3):340-50. Qin HS, Yu PP, Sun Y, Wang DF, Deng XF, Bao YL*, Song J*, Sun LG, Song ZB and Li YX. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress. MOL MED REP. 2016,13(5): 5118-5124. Danfeng Wang, Yuqing Zhao, Yimeng Wang, Yan Rong, Hongshuang Qin,Yongli Bao*, Zhenbo Song, Chunlei Yu, Luguo Sun, and Yuxin Li*. 25-methoxyl-dammarane-3,12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation partially through down-regulation of testes-specific protease 50 expression. Tumor Biology. 2016, First online: 02 April 2016 pp 1-9. 通讯作者 Huang YX ***, Zhao J, Song QH, Zheng LH, Fan C, Liu TT, Bao YL, Sun LG, Zhang LB*, Li YX**.Virtual screening and experimental validation of novel histone deacetylase inhibitors. TUMOR BIOLOGY,2016,37(9): 11805-11813通讯作者 Li ZJ, Wang YC, Jiang Bin, Li WL**, Zheng LH,Yang XG, Bao YL, Sun LG,Huang YX, Li YX*.Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea. J ETHNOPHARMACOL.2016,184:119-127, 通讯作者 Li W, Jiang M, Cao Y, Yan L, Qi R, Li Y*, Jing X.Turning Ineffective Transplatin into a Highly Potent Anticancer Drug via a Prodrug Strategy for Drug Delivery and Inhibiting Cisplatin Drug Resistance.Bioconjug Chem. 2016 Aug 17;27(8):1802-6. 通讯作者 Sun PP, Qi JL, Zhao YZ, Huang YX, Yang GF*, Ma ZQ**, Li YX***.A novel conformational B-cell epitope prediction method based on mimotope and patch analysis. J THEOR BIOL,2016,394:102-108. 通讯作者 Yue Cao, Xiaoguang Yang, Yannan Wu, Jingwen Yi, Yin Wu,c Chunlei Yu, Yanxin Huang, Yongli Bao***, Luguo Sun* and Yuxin Li**. Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model. RSC Adv., 2016, 6, 111440–111446通讯作者 Yue Cao, Yan Li, Yin Wu, Wenliang Li, Chunlei Yu, Yanxin Huang, Luguo Sun,*Yongli Bao*** and Yuxin Li**.Co-Delivery of angiostatin and curcumin by a biodegradable polymersome for antiangiogenic therapy. RSC Adv., 2016, 6, 105442–105448通讯作者 Feng Zhang, Bo Yang, Kailiang Zhang, Mei-Ling Hou, Xue-chun Lu, Yu-Xin Li. CCND1-BCL2 Gene Network: A direct target of Amifostine inhuman acute megakaryocytic leukemia cells. Chem Biol Drug Des 2016,DOI: 10.1111/cbdd.12889 Song ZB, Ni JS, Wu P, Bao YL*, Liu T, Li M, Fan C, Zhang WJ, Sun LG, Huang YX, Li YX*. Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB- dependent matrix metalloproteinase-9 expression. Cell Death Dis. 2015,6:e1703. 通讯作者 Yang C, Zhang DM, Song ZB, Hou YQ, Bao YL*, Sun LG**, Yu CL, and LiYX. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e0145095. Zhang Y, Guo GN, Ma B, Du R, Xiao HH, Yang XG, Li WL**, Gao Y, Li YX*, Jing XB. A hybrid platinum drug dichloroacetate-platinum(II) overcomes cisplatin drug resistance through dual organelle targeting. ANTI-CANCER DRUGS,2015,26(7):98-705通讯作者 Yi JW, Yang XG*, Zheng LH, Yang G, Sun LG, Bao YL, Wu Y, Huang YX, Yu CL, Yang SN***, Li YX**.Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. BIOSCIENCE REP,2015,35(3) :e00195-1-13通讯作者 Wang HY, Huang YX*, Zheng LH, Bao YL, Sun LG, Wu Y, Yu CL, Song ZB,Sun Y, Wang GN, Ma ZQ**, Li YX***.Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model. COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE,2015:387409-1-16, 通讯作者 Sun PP, Ju HX, Zhang BW, Gu Y, Liu B, Huang YX, Zhang HJ*, Li YX**. Conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis.BIOMED RESEARCH INTERNATIONAL,2015:257030-1-8, 通讯作者 Zhen Bo Song, BiaoLiu, YuYin Li, PingWu,Yong Li Bao *, YanXinHuang, YinWu, Lu Guo Sun ,Chun Lei Yu, Ying Sun , Li Hua Zheng , Yu Xin Li *. The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation. Cellular Signalling. 2014,26:2266-2275通讯作者 Xu-Guang Mi, Zhen-Bo Song, Ping Wu, Yu-Wei Zhang, Lu-Guo Sun, Yong-Li Bao*,Yu Zhang, Li-Hua Zheng, Ying Sun, Chun-Lei Yu, Yin Wu*, Guan-Nan Wang,Yu-Xin Li. Alantolactone induces cell apoptosis partially throughdown-regulation of testes-specific protease 50 expression. Toxicology Letters 224 (2014) 349-355 Jing Sun, Chan Zhang, Yong-Li Bao*, Yin Wu, Zhong-Liang Chen, Chun- Lei Yu, Yan-Xin Huang, Ying Sun, Li-Hua Zheng, Xue Wang, Yu-Xin Li*. Parthenolide-Induced Apoptosis, Autophagy and Suppression of Proliferation in HepG2 Cells. Asian Pacific Journal of Cancer Prevention, 2014,15,4897-4902, 通讯作者 Hua Lin, Yu-Wei Zhang, Ying Hua, Yong-Li Bao, Yin Wu, Lu-Guo Sun, Chun-Lei Yu, Yan-Xin Huang, En-Bo Wang, Hong-Yu Jiang , Yu-Xin Li.Three new compounds from the stem bark of Juglans mandshurica. Journal of Asian Natural Products Research, 2014,16,( 8): 819-824 Rong Du, Haihua Xiao, Guannan Guo, Bin Jiang, Xing Yan, Wenliang Li*,Xiaoguang Yang, Yu Zhang, Yuxin Li*, Xiabin Jing.*Nanoparticle delivery of photosensitive Pt(IV) drugs forcircumventing cisplatin cellular pathway and on-demand drug release. Colloids and Surfaces B: Biointerfaces.123 (2014):734-741, 通讯作者 Yun-feng Qi, Yan-xin Huang*, Yan Dong, Li-hua Zheng, Yong-li Bao, Lu-guo Sun, YinWu, Chun-lei Yu, Hong-yu Jiang, and Yu-xin Li*.Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors. Computational and Mathematical Methods in Medicine.2014, 867289:1-15通讯作者 Shao-Nian Yang, Yue Shi, Guang Yang, Yuxin Li, Jia Yu, Per-Olof Berggren*. Ionic mechanisms in pancreatic β cell signaling. Cellular and Molecular Life Sciences.2014, 71(21):4149–4177 Li Bingjin,Tang Fang***,Wang Liang,Liu Lei,Zhao Jinf,Zhou Yang, Wang Yinuo,Song Yunong,LiYuxin**,Cui Ranji*.Anticonvulsant Effects of Fuzi Total Alkaloid on Pentylenetetrazole-Induced Seizure in Mice.J PHARMACOL SCI,2013(123)195-198通讯作者 Meng Yuejuan,Zhang Yuwei,Jiang Hongyu***,Bao Yongli,Wu Yin*,Sun Luguo,Yu Chunlei,Huang Yanxin,Li Yuxin**. Chemical constituents from the roots of Zizyphus jujuba Mill. Var. spinosa, BIOCHEM SYST ECOL2013,50:182-186通讯作者 Lin Hua,Zhang Yuwei**,Bao Yongli,Wu Yin,Sun Luguo,Yu Chunlei,Huang Yanxin,Wang Enbo***,LiYuxin*. Secondary metabolites from the stem bark of Juglans mandshurica.BIOCHEM SYST ECOL2013,51184-188通讯作者 Yu Zhang, Yongli Bao*,Yin Wu,Chunlei Yu,Yanxin Huang,Ying Sun,Lihua Zheng,Yuxin Li**.Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. 2013,MOL MED REP(8):967-972通讯作者 Linchong Wang*,Yaqin Hou,Haihua Quan,Weiwei Xu,Yongli Bao**,Yuxin Li,Yuan Fu,Shuxue Zou.A compound-based computational approach for the accurate determination of hot spots. 2013,PROTEIN SCI(22)1060-1070 Jianzhong Wang,Lishan Wu,Jun Kong*,Yuxin Li**,Baoxue Zhang***.Maximum weight and minimum redundancy: A novel framework for feature subset selection. 2013,PATTERN RECOGN,46(6)1616-1627通讯作者 Sun Pingping,Ju Haixu,Liu Zhenbang,Ning Qiao,Zhang Jian,Zhao Xiaowei,Huang Yanxin,Ma Zhiqiang*,Li Yuxin**. Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2013,943636-1-11通讯作者 Wang Hongyan,Huang Yanxin*,Qi Yunfeng,Zhang Yu,Bao Yongli,Sun Luguo,Zheng Lihua,Zhang Yuwei,Ma Zhiqiang***,Li Yuxin**.Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis. THEORETICAL BIOLOGY AND MEDICAL MODELLING, 2013,10(1)27通讯作者 Niu Tianzeng,Zhang Yuwei*,Bao Yongli,Wu Yin**,Yu Chunlei,Sun Luoguo,Yi Jingwen,Huang Yanxin, Li Yuxin***.A validated high-performance liquid chromatography method with diode array detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less. J PHARMACEUT BIOMED,201376:44-48通讯作者 Wang Yunchao,Zhang Yuwei,Zheng Lihua,Bao Yongli,Wuyin*,Yu Chunlei,Huang Yanxin,Sun Luguo,Zhang Yu,Jia Xiujuan,Li Yuxin**. Four New Alkaloids from the Fermentation Broth of Armillaria mellea. HELV CHIM ACTA.2013,96:330-337通讯作者 Qi Yunfeng,Huang Yanxin*,Wang Hongyan,Zhang Yu,Bao Yongli,Sun Luoguo,Wu Yin,Yu Chunlei, Song Zhenbo,Zheng Lihua,Sun Ying,Wang Guannan,Li Yuxin**.Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modeling.BMC BIOINFORMATICS2013,14(41):1-21通讯作者 Wang Yunchao,Zhang Yuwei,Zheng Lihua,Bao Yongli,Wu Yin**,Yu Chunlei,Sun Luoguo,Zhang Yu,Huang Yanxin,Sun Ying,Li Yuxin**. A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration.J ASIAN NAT PROD RES,2013,15(2):203-208通讯作者 作为项目负责人近年承担的主要任务(2013年至今) 1.综合性干细胞库技术体系开发, 吉林省太阳鸟再生医学工程有限责任公司, 450万元,2016-09 - 2019-09 2.中药新药“艾可定”胶囊研发, 东北师范大学遗传与细胞研究所,301万元,2015-01 - 2017-12 3. 睾丸特异性蛋白50在乳腺癌侵袭及转移中的作用及机制研究,国家自然科学基金委,80万元,2013.1-2016.12 4.吉林省人类干细胞库创新研究中心, 吉林省科技厅, 20万元,2017.1-2018.12 5. 吉林省人类干细胞库工程研究中心,吉林省科技厅,50万元,2014.1-2015.12 6. 人类干细胞库国际联合研究中心, 长春市科技局, 20万元,2013-12 - 2015-12 近年授权专利(2013年至今) (1) Use of ethyl P-Methoxycinnamate and derivaives thereof in maintaining self-renewal and pluripotency of stem cell. 澳大利亚, PCT/CN2015/000311,2017-05-05,排序2/3 (2) Ostopanic acid 类似物及制备方法及用途.中国,201110433279.9,2016-05-04 ,排序1/6 (3) 薯蓣皂苷元及其衍生物在制备肿瘤化疗增敏药物中的应用.中国,201010557240.3,排序2/4 (4)楸皮新酸及其衍生物和它们的制备方法及医学用途。中国,201110053351.5,2013-11-06,排序1/6 (5)一种蒽醌类化合物及其赖氨酸盐的制备方法及医药用途。中国,201010110523.3,2013-08-14 ,排序1/8 近年受理专利(2015年至今) (1)血竭素、血竭素衍生物或其可用盐在制备糖尿病药物中的应用, 201710089562.1, 2017.2.20,排名2/8 (2)组载体及其构建方法、人Pdx1基因表达调节剂筛选细胞及筛选方法, 201710089563.6, 2017.2.20,排名1/5 (3)一种蒽醌类化合物及其制备方法和医用用途, 201611138847.1, 2016.12.12,排名1/3 (4)一种杠柳苷元及其衍生物用于防治皮肤增殖性疾病的应用, 201510811907.0, 2015.11.19,排名2/4 (5)对甲氧基桂皮酸乙酯及其衍生物在维持干细胞自我更新和多潜能性中的应用, 201510036595.0, 2015.1.26,排名2/3 (6)氯化两面针碱及其衍生物在制备防治皮肤病药物中的应用, 201510046580.2, 2015.1.30,排名2/4 (7)一种海藻多糖P155及其制备工艺, 201610591201.2, 2016.7.27,排名2/6 3.科研教学获奖(2014年至今) (1)“抗肿瘤药物筛选体系的建立及其创新药物筛”,选吉林省科学技术奖技术发明奖一等奖,吉林省科技厅,2016年,排序1/15 (2)“睾丸特异性蛋白酶50在肿瘤发生中的作用及机制研究”,吉林省自然科学学术成果奖二等奖,吉林省自然科学学术成果奖评审委员会2014年,排序2/7

社会兼职

  • 中国免疫学杂志编委
  • 中国生物制品杂志编委
  • 中国中医药年鉴编委
  • 中国药学会生物技术药物委员会委员
  • 中国医药商会专家委员会委员
  • 国家知识产权战略专家
  • 国家新产品计划专家
  • 国家生物产业(长春)基地首席专家

获奖情况

  • 科研教学获奖(2014年至今)
    (1)“抗肿瘤药物筛选体系的建立及其创新药物筛”,选吉林省科学技术奖技术发明奖一等奖,吉林省科技厅,2016年,排序1/15
    (2)“睾丸特异性蛋白酶50在肿瘤发生中的作用及机制研究”,吉林省自然科学学术成果奖二等奖,吉林省自然科学学术成果奖评审委员会2014年,排序2/7

教学信息

  • 1.讲授课程名称、课程类别及授课对象
    主要参与了现代生物技术进展、生物技术实践、基因工程技术、免疫学进展等课程的讲授。
    
    2.博士及硕士研究生招生
    硕士:分子生物学
    博士:细胞生物学
    招生信息详见国家工程实验室网站:http://www.neldgps.com/rencaipeiyang/910861

科研信息

  • 取得的主要科研教学成果(2013年至今)
    1.学术论文
               Yucui Liu, Yanjie Xu, Qiuhang Song, Fei Wang, Luguo Sun**, Lei Liu, Xiaoguang Yang, Jingwen Yi, Yongli Bao, Haifeng Ma, Honglan Huang***. Chunlei Yu,Yanxin Huang, Yin Wu* and Yuxin Li. Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans. Frontiers in Microbiology.2017,8, doi: 10.3389/fmicb.2017.01738
               Z-B Song, P Wu, J-S Ni, T Liu, C Fan, Y-L Bao*, Y Wu, L-G Sun, C-L Yu,Y-X Huang and Y-X Li**. Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene, 2017,doi:10.1038/onc.2017.198.通讯作者
               Yan Li , Yannan Wu , Xinlei Yao, Fang Hao , Chunlei Yu , Yongli Bao , Yin Wu , Zhenbo Song, Ying Sun , Lihua Zheng , Guannan Wang , Yanxin Huang , Luguo Sun* , and.Yuxin Li*.Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo.Int. J. Mol. Sci. 2017, 18, 794,doi:10.3390/ ijms18040794通讯作者
               Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao* , Yuxin Li**.Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling. Molecular Immunology. 2017,82: Pages 94–103通讯作者
               Yuwei Zhang, Hua Lin,Shanshan Li,Jianbo Chen,Yinshi Sun,Yuxin Li*. High-speed counter-current chromatography assisted preparative isolation of bioactive compounds from stem bark of Juglans mandshurica.J Sep Sci. 2017 Feb;40(3):767-778,通讯作者
               Zhang WJ, Song ZB, Bao YL*, Li WL, Yang XG, Wang Q, Yu CL, Sun LG, Huang YX and Li YX*. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016, 105:66-79. 通讯作者
               Mi XG, Song ZB, Sun LG, Bao YL**, Yu CL, Wu Y*, Li YX. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. Int J Biochem Cell Biol. 2016 ,73: 63–71.
               Hou YQ, Yao Y, Bao YL*, Song ZB*, Yang C, Gao XL, Zhang WJ, Sun LG, Yu CL, Huang YX,Wang GN, Li YX. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HepG2 cells. Oxid Med Cell Longev. 2016:4941623. 
               Gao XL, Lin H, Zhao W, Hou YQ, Bao YL*, Song ZB, Sun LG, Tian SY, Liu B*, Li YX. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. Apoptosis. 2016,21(3):340-50. 
               Qin HS, Yu PP, Sun Y, Wang DF, Deng XF, Bao YL*, Song J*, Sun LG, Song ZB and Li YX. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress. MOL MED REP. 2016,13(5): 5118-5124. 
               Danfeng Wang, Yuqing Zhao, Yimeng Wang, Yan Rong, Hongshuang Qin,Yongli Bao*, Zhenbo Song, Chunlei Yu, Luguo Sun, and Yuxin Li*. 25-methoxyl-dammarane-3,12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation partially through down-regulation of testes-specific protease 50 expression. Tumor Biology. 2016, First online: 02 April 2016 pp 1-9. 通讯作者
               Huang YX ***, Zhao J, Song QH, Zheng LH, Fan C, Liu TT, Bao YL, Sun LG, Zhang LB*, Li YX**.Virtual screening and experimental validation of novel histone deacetylase inhibitors. TUMOR BIOLOGY,2016,37(9): 11805-11813通讯作者
               Li ZJ, Wang YC, Jiang Bin, Li WL**, Zheng LH,Yang XG, Bao YL, Sun LG,Huang YX, Li YX*.Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea. J ETHNOPHARMACOL.2016,184:119-127, 通讯作者
               Li W, Jiang M, Cao Y, Yan L, Qi R, Li Y*, Jing X.Turning Ineffective Transplatin into a Highly Potent Anticancer Drug via a Prodrug Strategy for Drug Delivery and Inhibiting Cisplatin Drug Resistance.Bioconjug Chem. 2016 Aug 17;27(8):1802-6. 通讯作者
               Sun PP, Qi JL, Zhao YZ, Huang YX, Yang GF*, Ma ZQ**, Li YX***.A novel conformational B-cell epitope prediction method based on mimotope and patch analysis. J THEOR BIOL,2016,394:102-108. 通讯作者     
               Yue Cao, Xiaoguang Yang, Yannan Wu, Jingwen Yi, Yin Wu,c Chunlei Yu, Yanxin Huang, Yongli Bao***, Luguo Sun* and Yuxin Li**. Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model. RSC Adv., 2016, 6, 111440–111446通讯作者
               Yue Cao, Yan Li, Yin Wu, Wenliang Li, Chunlei Yu, Yanxin Huang, Luguo Sun,*Yongli Bao*** and Yuxin Li**.Co-Delivery of angiostatin and curcumin by a biodegradable polymersome for antiangiogenic therapy. RSC Adv., 2016, 6, 105442–105448通讯作者
               Feng Zhang, Bo Yang, Kailiang Zhang, Mei-Ling Hou, Xue-chun Lu, Yu-Xin Li. CCND1-BCL2 Gene Network: A direct target of Amifostine inhuman acute megakaryocytic leukemia cells. Chem Biol Drug Des 2016,DOI: 10.1111/cbdd.12889
               Song ZB, Ni JS, Wu P, Bao YL*, Liu T, Li M, Fan C, Zhang WJ, Sun LG, Huang YX, Li YX*. Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB- dependent matrix metalloproteinase-9 expression. Cell Death Dis. 2015,6:e1703. 通讯作者
               Yang C, Zhang DM, Song ZB, Hou YQ, Bao YL*, Sun LG**, Yu CL, and LiYX. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e0145095. 
               Zhang Y, Guo GN, Ma B, Du R, Xiao HH, Yang XG, Li WL**, Gao Y, Li YX*, Jing XB. A hybrid platinum drug dichloroacetate-platinum(II) overcomes cisplatin drug resistance through dual organelle targeting. ANTI-CANCER DRUGS,2015,26(7):98-705通讯作者
               Yi JW, Yang XG*, Zheng LH, Yang G, Sun LG, Bao YL, Wu Y, Huang YX, Yu CL, Yang SN***, Li YX**.Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. BIOSCIENCE REP,2015,35(3) :e00195-1-13通讯作者
               Wang HY, Huang YX*, Zheng LH, Bao YL, Sun LG, Wu Y, Yu CL, Song ZB,Sun Y, Wang GN, Ma ZQ**, Li YX***.Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model. COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE,2015:387409-1-16, 通讯作者
               Sun PP, Ju HX, Zhang BW, Gu Y, Liu B, Huang YX, Zhang HJ*, Li YX**. Conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis.BIOMED RESEARCH INTERNATIONAL,2015:257030-1-8, 通讯作者
               Zhen Bo Song, BiaoLiu, YuYin Li, PingWu,Yong Li Bao *, YanXinHuang, YinWu, Lu Guo Sun ,Chun Lei Yu, Ying Sun , Li Hua Zheng , Yu Xin Li *. The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation. Cellular Signalling. 2014,26:2266-2275通讯作者
               Xu-Guang Mi, Zhen-Bo Song, Ping Wu, Yu-Wei Zhang, Lu-Guo Sun, Yong-Li Bao*,Yu Zhang, Li-Hua Zheng, Ying Sun, Chun-Lei Yu, Yin Wu*, Guan-Nan Wang,Yu-Xin Li. Alantolactone induces cell apoptosis partially throughdown-regulation of testes-specific protease 50 expression. Toxicology Letters 224 (2014) 349-355
               Jing Sun, Chan Zhang, Yong-Li Bao*, Yin Wu, Zhong-Liang Chen, Chun- Lei Yu, Yan-Xin Huang, Ying Sun, Li-Hua Zheng, Xue Wang, Yu-Xin Li*. Parthenolide-Induced Apoptosis, Autophagy and Suppression of Proliferation in HepG2 Cells. Asian Pacific Journal of Cancer Prevention, 2014,15,4897-4902, 通讯作者
               Hua Lin, Yu-Wei Zhang, Ying Hua, Yong-Li Bao, Yin Wu, Lu-Guo Sun, Chun-Lei Yu, Yan-Xin Huang, En-Bo Wang, Hong-Yu Jiang , Yu-Xin Li.Three new compounds from the stem bark of Juglans mandshurica. Journal of Asian Natural Products Research, 2014,16,( 8): 819-824
               Rong Du, Haihua Xiao, Guannan Guo, Bin Jiang, Xing Yan, Wenliang Li*,Xiaoguang Yang, Yu Zhang, Yuxin Li*, Xiabin Jing.*Nanoparticle delivery of photosensitive Pt(IV) drugs forcircumventing cisplatin cellular pathway and on-demand drug release. Colloids and Surfaces B: Biointerfaces.123 (2014):734-741, 通讯作者 
               Yun-feng Qi, Yan-xin Huang*, Yan Dong, Li-hua Zheng, Yong-li Bao, Lu-guo Sun, YinWu, Chun-lei Yu, Hong-yu Jiang, and Yu-xin Li*.Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors. Computational and Mathematical Methods in Medicine.2014, 867289:1-15通讯作者
               Shao-Nian Yang, Yue Shi, Guang Yang, Yuxin Li, Jia Yu, Per-Olof Berggren*. Ionic mechanisms in pancreatic β cell signaling. Cellular and Molecular Life Sciences.2014, 71(21):4149–4177
               Li Bingjin,Tang Fang***,Wang Liang,Liu Lei,Zhao Jinf,Zhou Yang, Wang Yinuo,Song Yunong,LiYuxin**,Cui Ranji*.Anticonvulsant Effects of Fuzi Total Alkaloid on Pentylenetetrazole-Induced Seizure in Mice.J PHARMACOL SCI,2013(123)195-198通讯作者
               Meng Yuejuan,Zhang Yuwei,Jiang Hongyu***,Bao Yongli,Wu Yin*,Sun Luguo,Yu Chunlei,Huang Yanxin,Li Yuxin**. Chemical constituents from the roots of Zizyphus jujuba Mill. Var. spinosa, BIOCHEM SYST ECOL2013,50:182-186通讯作者
               Lin Hua,Zhang Yuwei**,Bao Yongli,Wu Yin,Sun Luguo,Yu Chunlei,Huang Yanxin,Wang Enbo***,LiYuxin*. Secondary metabolites from the stem bark of Juglans mandshurica.BIOCHEM SYST ECOL2013,51184-188通讯作者
               Yu Zhang, Yongli Bao*,Yin Wu,Chunlei Yu,Yanxin Huang,Ying Sun,Lihua Zheng,Yuxin Li**.Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. 2013,MOL MED REP(8):967-972通讯作者
               Linchong Wang*,Yaqin Hou,Haihua Quan,Weiwei Xu,Yongli Bao**,Yuxin Li,Yuan Fu,Shuxue Zou.A compound-based computational approach for the accurate determination of hot spots. 2013,PROTEIN SCI(22)1060-1070
               Jianzhong Wang,Lishan Wu,Jun Kong*,Yuxin Li**,Baoxue Zhang***.Maximum weight and minimum redundancy: A novel framework for feature subset selection. 2013,PATTERN RECOGN,46(6)1616-1627通讯作者
               Sun Pingping,Ju Haixu,Liu Zhenbang,Ning Qiao,Zhang Jian,Zhao Xiaowei,Huang Yanxin,Ma Zhiqiang*,Li Yuxin**. Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2013,943636-1-11通讯作者
               Wang Hongyan,Huang Yanxin*,Qi Yunfeng,Zhang Yu,Bao Yongli,Sun Luguo,Zheng Lihua,Zhang Yuwei,Ma Zhiqiang***,Li Yuxin**.Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis. THEORETICAL BIOLOGY AND MEDICAL MODELLING, 2013,10(1)27通讯作者
               Niu Tianzeng,Zhang Yuwei*,Bao Yongli,Wu Yin**,Yu Chunlei,Sun Luoguo,Yi Jingwen,Huang Yanxin, Li Yuxin***.A validated high-performance liquid chromatography method with diode array detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less. J PHARMACEUT BIOMED,201376:44-48通讯作者
               Wang Yunchao,Zhang Yuwei,Zheng Lihua,Bao Yongli,Wuyin*,Yu Chunlei,Huang Yanxin,Sun Luguo,Zhang Yu,Jia Xiujuan,Li Yuxin**. Four New Alkaloids from the Fermentation Broth of Armillaria mellea. HELV CHIM ACTA.2013,96:330-337通讯作者
               Qi Yunfeng,Huang Yanxin*,Wang Hongyan,Zhang Yu,Bao Yongli,Sun Luoguo,Wu Yin,Yu Chunlei, Song Zhenbo,Zheng Lihua,Sun Ying,Wang Guannan,Li Yuxin**.Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modeling.BMC BIOINFORMATICS2013,14(41):1-21通讯作者
               Wang Yunchao,Zhang Yuwei,Zheng Lihua,Bao Yongli,Wu Yin**,Yu Chunlei,Sun Luoguo,Zhang Yu,Huang Yanxin,Sun Ying,Li Yuxin**. A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration.J ASIAN NAT PROD RES,2013,15(2):203-208通讯作者
    
    作为项目负责人近年承担的主要任务(2013年至今)
    1.综合性干细胞库技术体系开发, 吉林省太阳鸟再生医学工程有限责任公司, 450万元,2016-09 - 2019-09 
    2.中药新药“艾可定”胶囊研发, 东北师范大学遗传与细胞研究所,301万元,2015-01 - 2017-12 
    3. 睾丸特异性蛋白50在乳腺癌侵袭及转移中的作用及机制研究,国家自然科学基金委,80万元,2013.1-2016.12 
    4.吉林省人类干细胞库创新研究中心, 吉林省科技厅, 20万元,2017.1-2018.12
    5. 吉林省人类干细胞库工程研究中心,吉林省科技厅,50万元,2014.1-2015.12 
    6. 人类干细胞库国际联合研究中心, 长春市科技局, 20万元,2013-12 - 2015-12 
    
    近年授权专利(2013年至今)
     (1) Use of ethyl P-Methoxycinnamate and derivaives thereof in maintaining self-renewal and pluripotency of stem cell. 澳大利亚, PCT/CN2015/000311,2017-05-05,排序2/3
    (2) Ostopanic acid 类似物及制备方法及用途.中国,201110433279.9,2016-05-04 ,排序1/6
    (3) 薯蓣皂苷元及其衍生物在制备肿瘤化疗增敏药物中的应用.中国,201010557240.3,排序2/4
    (4)楸皮新酸及其衍生物和它们的制备方法及医学用途。中国,201110053351.5,2013-11-06,排序1/6
    (5)一种蒽醌类化合物及其赖氨酸盐的制备方法及医药用途。中国,201010110523.3,2013-08-14 ,排序1/8
    
    近年受理专利(2015年至今)
    (1)血竭素、血竭素衍生物或其可用盐在制备糖尿病药物中的应用, 201710089562.1, 2017.2.20,排名2/8
    (2)组载体及其构建方法、人Pdx1基因表达调节剂筛选细胞及筛选方法, 201710089563.6, 2017.2.20,排名1/5
    (3)一种蒽醌类化合物及其制备方法和医用用途, 201611138847.1,  2016.12.12,排名1/3
    (4)一种杠柳苷元及其衍生物用于防治皮肤增殖性疾病的应用, 201510811907.0, 2015.11.19,排名2/4
    (5)对甲氧基桂皮酸乙酯及其衍生物在维持干细胞自我更新和多潜能性中的应用, 201510036595.0, 2015.1.26,排名2/3
    (6)氯化两面针碱及其衍生物在制备防治皮肤病药物中的应用, 201510046580.2, 2015.1.30,排名2/4
    (7)一种海藻多糖P155及其制备工艺, 201610591201.2, 2016.7.27,排名2/6
    
    3.科研教学获奖(2014年至今)
    (1)“抗肿瘤药物筛选体系的建立及其创新药物筛”,选吉林省科学技术奖技术发明奖一等奖,吉林省科技厅,2016年,排序1/15
    (2)“睾丸特异性蛋白酶50在肿瘤发生中的作用及机制研究”,吉林省自然科学学术成果奖二等奖,吉林省自然科学学术成果奖评审委员会2014年,排序2/7
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