职  称:副教授
研究方向:肿瘤发生机制
办公电话:89165911
办公地点:净月校区药物基因和蛋白筛选过程工程实验室
电子邮件:songzb484@nenu.edu.cn

个人简历

现为东北师范大学生命科学学院讲师,一直从事肿瘤发生机制和抗肿瘤药物筛选的研究。在国际著名期刊 Oncogene,Cell Death Dis,cell signal等发表SCI论文18篇,主持了2个C类科研项目以及1个D类项目和1个E类项目,并获得科研奖励2项。主要承担生物技术专业技术实践课和蛋白质与酶工程课程。 2015-至今 东北师范大学 讲师 2013年5月~2015年5月 东北师范大学化学学院博士后研究 2006年9月~2011年7月 东北师范大学遗传与细胞研究所 硕博连读 2002年9月~2006年7月 河南师范大学生命科学学院理学学士

社会兼职

  • 细胞生物学和免疫学会会员

获奖情况

  • 吉林省科学技术奖	  B类	吉林省科学技术奖励委员会	一等	2016.11
    吉林省自然科学学术成果奖	其它	吉林省自然科学学术成果奖评审委员会	二等	2014.9

教学信息

  • 1.生物技术专业实践课
    2.蛋白质与酶工程

科研信息

  • SCI 论文
    1.Song ZB, Wu P, Ni JS, Liu T, Fan C, Bao YL, Wu Y, Sun LG, Yu CL, Huang YX, Li YX (2017) Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene. doi:10.1038/onc.2017.198
    2.Song ZB, Ni JS, Bao YL*, et al. (2015.)Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression [J]. Cell Death Dis,6e1703
    3.Song ZB, Liu B, Bao YL*, et al. 2014.The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation [J]. cellular signalling, 26(10):2266-2275
    4.Zhenbo Song, Yongli Bao*, Yu Zhang, Xuguang Mi, Ping Wu, Yin Wu, ChunLei Yu, Ying Sun, LiHua Zheng, YanXin Huang, Biao Liu and YuXin Li*.Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the NF-kappa beta (NF-κB) signaling pathway. Biochem J. 2011 Jun 1;436(2):457-67.
    5.Yaqin Hou, Yao Yao, Yongli Bao*, Zhenbo Song*, Cheng Yang, Xiuli Gao, Wenjing Zhang, Luguo Sun, Chunlei Yu, Yanxin Huang, Guannan Wang, Yuxin Li. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HepG2 cells. Oxid Med Cell Longev. 2016:4941623.
    6.Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun*, Yuxin Li*. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4). pii: E794. doi: 10.3390/ijms18040794
    7.Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao*, Yuxin Li*. Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling. Mol Immunol. 2017;82:94-103.
    8.Wenjing Zhang, Zhenbo Song, Yongli Bao *, Wenling Li, Xiaoguang Yang, Qi Wang, Chunlei Yu, Luguo Sun, Yanxin Huang, Yuxin Li *. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016; 105:66-79.
    9.Danfeng Wang, Yuqing Zhao, Yimeng Wang, Yan Rong, Hongshuang Qin, Yongli Bao*, Zhenbo Song, Chunlei Yu, Luguo Sun, Yuxin Li*. 25-methoxyl- dammarane-3, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation partially through down-regulation of testes-specific protease 50 expression. Tumor Biology, 2016, 37(9):11805-11813.
    10.Hongshuang Qin, Peipei Yu, Ying Sun, Danfeng Wang, Xiaofen Deng, Yongli Bao*, Jun Song*, Luguo Sun, Zhenbo Song, Yuxin Li. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress. MOL MED REP. 2016,13(5): 5118-5124.
    11.Xiuli Gao, Hua Lin, Wei Zhao, Yaqin Hou, Yongli Bao*, Zhenbo Song, Luguo Sun, Shengyi Tian, Biao Liu*, Yuxin Li. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. Apoptosis. 2016,21(3):340-50. 
    12.Xuguang Mi, Zhenbo Song, Luguo Sun, Yongli Bao *, Chunlei Yu, Yin Wu, Yuxin Li. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. Int J Biochem Cell Biol. 2016 ,73: 63–71.
    13.Cheng Yang, Dongmei Zhang, Zhenbo Song, Yaqin Hou, Yongli Bao*, Luguo Sun*, Chunlei Yu, Yuxin Li. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e0145095.
    14.Hongyan Wang, Yanxin Huang*, Lihua Zheng, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, Zhenbo Song, Ying Sun, Guannan Wang, Zhiqiang Ma*, Yuxin Li*. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model.Computational Intellegence and Neruoscience, 2015, 2015:387409-1-16
    15.Xuguang Mi, Zhenbo Song, Ping Wu, Yuwei Zhang, Luguo Sun, Yongli Bao*,Yu Zhang, Lihua Zheng, Ying Sun, Chunlei Yu, Yin Wu*, Guannan Wang, Yuxin Li. Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression. Toxicology Letters, 2014, 224:349-355
    16.Yunfeng Qi, Yanxin Huang*, Hongyan Wang, Yu Zhang, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, zhenbo song, Lihua Zheng, Ying Sun, Guannan Wang, Yuxin Li*. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling. BMC Bioinformatics. 2013,14(1):41.
    17.Cong Fan, Yanxin Huang*, Yongli Bao*, Luguo Sun, Yin Wu, Chunei Yu, Yu Zhang, Zhenbo Song, Lihua Zheng, Ying Sun, Gjuannan Wang, Yuxin Li*. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database. Int J Mol Sci. 2012 Dec 14;13(12):17185-209.
    18.Yuyin Li, Yongli Bao*, Zhenbo Song, Luguo Sun, Ping Wu, Yu Zhang, Cong Fan, Yanxin Huang, Yin Wu, Chunlei Yu, Ying Sun, Lihua Zheng, Guannan Wang, and Yuxin Li*. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation. PLoS ONE. 2012, 7(5): e35030. Epub 2012 May 4. doi:10.1371/journal.pone.0035030.
    科研项目
    1.miRNA在TSP50诱导的乳腺癌发生中的作用及机制研究  国家自然科学基金青年项目	
    2.miR-4709-3p在TSP50相关的乳腺癌转移中的调节作用和机制研究	吉林省科技厅青年科研基金	
    3.TSP50蛋白酶活性中心催化三联体在其促肿瘤发生中的作用及机制研究 吉林省科技厅青年科研基金		.
    4.TSP50活性中心的催化三联体在细胞增殖和侵袭中的作用及机制研究	校内青年基金项目
信息维护