- 免疫学会会员
- 细胞生物学学会会员
- 线粒体协会会员
- 肿瘤标志委员会会员
宋振波
东北师范大学生命科学学院
职 称：副教授
研究方向：肿瘤发生机制
办公电话：89165911
办公地点：药物基因和蛋白筛选国家工程实验室
研究方向：肿瘤发生机制
办公电话：89165911
办公地点：药物基因和蛋白筛选国家工程实验室
个人简历
现为东北师范大学药物基因和蛋白筛选国家工程实验室副教授，硕士生导师，一直从事肿瘤发生机制和抗肿瘤药物筛选的研究。在国际著名期刊 Oncogene,Cell proliferation,Cell Death Dis，cell signal等发表SCI论文20余篇,主持了1个B类项目和3个C类科研项目，并获得科研奖励3项。主要承担本科生物技术专业技术实践课和蛋白质与酶工程课程和研究生细胞生物学实验技术与方法课程。 工作经历 2018年8月～2019年9月 美国明尼苏达大学 访问学者 2017年6月～至今 东北师范大学 副教授 2015年6月～2017年5月 东北师范大学 讲师 2013年5月～2015年5月 东北师范大学化学学院博士后研究 学习经历 2006年9月～2011年7月 东北师范大学遗传与细胞研究所 硕博连读 2002年9月～2006年7月 河南师范大学生命科学学院理学学士 主要科研方向 1.肿瘤发病机制研究 2.肿瘤代谢研究 2.抗肿瘤中药新药筛选 3.线粒体功能研究 硕士研究生招生专业 硕士招生专业：细胞生物学（国家工程实验室） 联系方式：电话：15943054200 QQ:295242943 微信：szb15943054200 邮箱：songzb484@nenu.edu.cn 科研成果 SCI 论文 1.Xiaojun Zhang, Feng Gao; Huihan Ai; Shuyue Wang; Zhenbo Song*; Lihua Zheng; Guannan Wang; Ying Sun; Yongli Bao* . TSP50 promotes hepatocyte proliferation and tumor formation by activating glucose-6-phosphate dehydrogenase (G6PD). Cell proliferation. (2021) online. DOI:10.1111/cpr.13015. 2.Feng Gao , Xiaojun Zhang , Shuyue Wang , Lihua Zheng , Ying Sun ,Guannan Wang , Zhenbo Song* and Yongli Bao. TSP50 promotes the Warburg effectnd hepatocyte proliferation via regulating PKM2 acetylation. Cell Death Dis. 2021 May 20;12(6):517. doi: 10.1038/s41419-021-03782-w. 3. Mei X, Zhao H, Ai H, Wang S, Song Z*, Zheng L, Wang G, Sun Y, Bao Y.Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways. Cell Biosci. 2021 Aug 4;11(1):156. doi: 10.1186/s13578-021-00669-3. 4.Wang, Y. , Xu, S. , Wang, S. , Song, Z*. , & Bao, Y , et al. miR-4709-3p Inhibits Cell Proliferation by Downregulating TSP50 Expression in Breast Cancer Cells[J]. DNA and cell biology, Jul;40(7):969-978. Epub 2021 May 5. 5. Ai HH, Liu B, Yang MT, Zuo QQ, Song ZB*, Bao YL*, Sun LG, Zhou L, Li YX. Expression and effects of TSP50 in mouse embryo and cardiac myocyte development. Biochem Biophys Res Commun. (2018) Jul 12;502(2):283-288. 6.Song ZB, Wu P, Ni JS, Liu T, Fan C, Bao YL, Wu Y, Sun LG, Yu CL, Huang YX, Li YX (2017) Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene. doi:10.1038/onc.2017.198 7.Song ZB, Ni JS, Bao YL*, et al. （2015.）Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression [J]. Cell Death Dis,6e1703 8.Song ZB, Liu B, Bao YL*, et al. 2014.The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation [J]. cellular signalling, 26(10):2266-2275 9.Zhenbo Song, Yongli Bao*, Yu Zhang, Xuguang Mi, Ping Wu, Yin Wu, ChunLei Yu, Ying Sun, LiHua Zheng, YanXin Huang, Biao Liu and YuXin Li*.Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the NF-kappa beta (NF-κB) signaling pathway. Biochem J. 2011 Jun 1;436(2):457-67. 10.Yaqin Hou, Yao Yao, Yongli Bao*, Zhenbo Song*, Cheng Yang, Xiuli Gao, Wenjing Zhang, Luguo Sun, Chunlei Yu, Yanxin Huang, Guannan Wang, Yuxin Li. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HepG2 cells. Oxid Med Cell Longev. 2016:4941623. 11.Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun*, Yuxin Li*. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4). pii: E794. doi: 12.3390/ijms18040794 12.Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao*, Yuxin Li*. Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling. Mol Immunol. 2017;82:94-103. 13.Wenjing Zhang, Zhenbo Song, Yongli Bao *, Wenling Li, Xiaoguang Yang, Qi Wang, Chunlei Yu, Luguo Sun, Yanxin Huang, Yuxin Li *. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016; 105:66-79. 14.Danfeng Wang, Yuqing Zhao, Yimeng Wang, Yan Rong, Hongshuang Qin, Yongli Bao*, Zhenbo Song, Chunlei Yu, Luguo Sun, Yuxin Li*. 25-methoxyl- dammarane-3, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation partially through down-regulation of testes-specific protease 50 expression. Tumor Biology, 2016, 37(9):11805-11813. 15.Hongshuang Qin, Peipei Yu, Ying Sun, Danfeng Wang, Xiaofen Deng, Yongli Bao*, Jun Song*, Luguo Sun, Zhenbo Song, Yuxin Li. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress. MOL MED REP. 2016,13(5): 5118-5124. 16.Xiuli Gao, Hua Lin, Wei Zhao, Yaqin Hou, Yongli Bao*, Zhenbo Song, Luguo Sun, Shengyi Tian, Biao Liu*, Yuxin Li. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. Apoptosis. 2016,21(3):340-50. 17.Xuguang Mi, Zhenbo Song, Luguo Sun, Yongli Bao *, Chunlei Yu, Yin Wu, Yuxin Li. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. Int J Biochem Cell Biol. 2016 ,73: 63–71. 18.Cheng Yang, Dongmei Zhang, Zhenbo Song, Yaqin Hou, Yongli Bao*, Luguo Sun*, Chunlei Yu, Yuxin Li. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e0145095. 19.Hongyan Wang, Yanxin Huang*, Lihua Zheng, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, Zhenbo Song, Ying Sun, Guannan Wang, Zhiqiang Ma*, Yuxin Li*. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model．Computational Intellegence and Neruoscience, 2015, 2015:387409-1-16 20.Xuguang Mi, Zhenbo Song, Ping Wu, Yuwei Zhang, Luguo Sun, Yongli Bao*,Yu Zhang, Lihua Zheng, Ying Sun, Chunlei Yu, Yin Wu*, Guannan Wang, Yuxin Li. Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression. Toxicology Letters, 2014, 224:349-355 21.Yunfeng Qi, Yanxin Huang*, Hongyan Wang, Yu Zhang, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, zhenbo song, Lihua Zheng, Ying Sun, Guannan Wang, Yuxin Li*. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling. BMC Bioinformatics. 2013,14(1):41. 22.Cong Fan, Yanxin Huang*, Yongli Bao*, Luguo Sun, Yin Wu, Chunei Yu, Yu Zhang, Zhenbo Song, Lihua Zheng, Ying Sun, Gjuannan Wang, Yuxin Li*. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database. Int J Mol Sci. 2012 Dec 14;13(12):17185-209. 23.Yuyin Li, Yongli Bao*, Zhenbo Song, Luguo Sun, Ping Wu, Yu Zhang, Cong Fan, Yanxin Huang, Yin Wu, Chunlei Yu, Ying Sun, Lihua Zheng, Guannan Wang, and Yuxin Li*. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation. PLoS ONE. 2012, 7(5): e35030. Epub 2012 May 4. doi:10.1371/journal.pone.0035030. 科研项目 1.脐带间充质干细胞外泌体在银屑病治疗中的作用和机制研究 吉林省科技厅重点科技研发项目医药健康领域 2.系列抗病毒消毒产品 吉林省科技厅重点科技研发项目 3.miRNA在TSP50诱导的乳腺癌发生中的作用及机制研究 国家自然科学基金青年项目 4.miR-4709-3p在TSP50相关的乳腺癌转移中的调节作用和机制研究 吉林省科技厅青年科研基金 5.TSP50蛋白酶活性中心催化三联体在其促肿瘤发生中的作用及机制研究 吉林省科技厅青年科研基金 6.TSP50活性中心的催化三联体在细胞增殖和侵袭中的作用及机制研究 校内青年基金项目
社会兼职
获奖情况
吉林省自然科学学术成果奖 吉林省自然科学学术成果奖评审委员会 三等 2018.5 吉林省科学技术奖 B类 吉林省科学技术奖励委员会 一等 2016.11 吉林省自然科学学术成果奖 其它 吉林省自然科学学术成果奖评审委员会 二等 2014.9
教学信息
1.生物技术专业实践课 2.蛋白质与酶工程 3.细胞生物学实验技术与方法
科研信息
SCI 论文 1.Xiaojun Zhang, Feng Gao; Huihan Ai; Shuyue Wang; Zhenbo Song*; Lihua Zheng; Guannan Wang; Ying Sun; Yongli Bao* . TSP50 promotes hepatocyte proliferation and tumor formation by activating glucose-6-phosphate dehydrogenase (G6PD). Cell proliferation. (2021) online. DOI:10.1111/cpr.13015. 2.Feng Gao , Xiaojun Zhang , Shuyue Wang , Lihua Zheng , Ying Sun ,Guannan Wang , Zhenbo Song* and Yongli Bao. TSP50 promotes the Warburg effectnd hepatocyte proliferation via regulating PKM2 acetylation. Cell Death Dis. 2021 May 20;12(6):517. doi: 10.1038/s41419-021-03782-w. 3. Mei X, Zhao H, Ai H, Wang S, Song Z*, Zheng L, Wang G, Sun Y, Bao Y.Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways. Cell Biosci. 2021 Aug 4;11(1):156. doi: 10.1186/s13578-021-00669-3. 4.Wang, Y. , Xu, S. , Wang, S. , Song, Z*. , & Bao, Y , et al. miR-4709-3p Inhibits Cell Proliferation by Downregulating TSP50 Expression in Breast Cancer Cells[J]. DNA and cell biology, Jul;40(7):969-978. Epub 2021 May 5. 5. Ai HH, Liu B, Yang MT, Zuo QQ, Song ZB*, Bao YL*, Sun LG, Zhou L, Li YX. Expression and effects of TSP50 in mouse embryo and cardiac myocyte development. Biochem Biophys Res Commun. (2018) Jul 12;502(2):283-288. 6.Song ZB, Wu P, Ni JS, Liu T, Fan C, Bao YL, Wu Y, Sun LG, Yu CL, Huang YX, Li YX (2017) Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene. doi:10.1038/onc.2017.198 7.Song ZB, Ni JS, Bao YL*, et al. （2015.）Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression [J]. Cell Death Dis,6e1703 8.Song ZB, Liu B, Bao YL*, et al. 2014.The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation [J]. cellular signalling, 26(10):2266-2275 9.Zhenbo Song, Yongli Bao*, Yu Zhang, Xuguang Mi, Ping Wu, Yin Wu, ChunLei Yu, Ying Sun, LiHua Zheng, YanXin Huang, Biao Liu and YuXin Li*.Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the NF-kappa beta (NF-κB) signaling pathway. Biochem J. 2011 Jun 1;436(2):457-67. 10.Yaqin Hou, Yao Yao, Yongli Bao*, Zhenbo Song*, Cheng Yang, Xiuli Gao, Wenjing Zhang, Luguo Sun, Chunlei Yu, Yanxin Huang, Guannan Wang, Yuxin Li. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HepG2 cells. Oxid Med Cell Longev. 2016:4941623. 11.Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun*, Yuxin Li*. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4). pii: E794. doi: 12.3390/ijms18040794 12.Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao*, Yuxin Li*. Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling. Mol Immunol. 2017;82:94-103. 13.Wenjing Zhang, Zhenbo Song, Yongli Bao *, Wenling Li, Xiaoguang Yang, Qi Wang, Chunlei Yu, Luguo Sun, Yanxin Huang, Yuxin Li *. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016; 105:66-79. 14.Danfeng Wang, Yuqing Zhao, Yimeng Wang, Yan Rong, Hongshuang Qin, Yongli Bao*, Zhenbo Song, Chunlei Yu, Luguo Sun, Yuxin Li*. 25-methoxyl- dammarane-3, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation partially through down-regulation of testes-specific protease 50 expression. Tumor Biology, 2016, 37(9):11805-11813. 15.Hongshuang Qin, Peipei Yu, Ying Sun, Danfeng Wang, Xiaofen Deng, Yongli Bao*, Jun Song*, Luguo Sun, Zhenbo Song, Yuxin Li. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress. MOL MED REP. 2016,13(5): 5118-5124. 16.Xiuli Gao, Hua Lin, Wei Zhao, Yaqin Hou, Yongli Bao*, Zhenbo Song, Luguo Sun, Shengyi Tian, Biao Liu*, Yuxin Li. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. Apoptosis. 2016,21(3):340-50. 17.Xuguang Mi, Zhenbo Song, Luguo Sun, Yongli Bao *, Chunlei Yu, Yin Wu, Yuxin Li. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. Int J Biochem Cell Biol. 2016 ,73: 63–71. 18.Cheng Yang, Dongmei Zhang, Zhenbo Song, Yaqin Hou, Yongli Bao*, Luguo Sun*, Chunlei Yu, Yuxin Li. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e0145095. 19.Hongyan Wang, Yanxin Huang*, Lihua Zheng, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, Zhenbo Song, Ying Sun, Guannan Wang, Zhiqiang Ma*, Yuxin Li*. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model．Computational Intellegence and Neruoscience, 2015, 2015:387409-1-16 20.Xuguang Mi, Zhenbo Song, Ping Wu, Yuwei Zhang, Luguo Sun, Yongli Bao*,Yu Zhang, Lihua Zheng, Ying Sun, Chunlei Yu, Yin Wu*, Guannan Wang, Yuxin Li. Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression. Toxicology Letters, 2014, 224:349-355 21.Yunfeng Qi, Yanxin Huang*, Hongyan Wang, Yu Zhang, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, zhenbo song, Lihua Zheng, Ying Sun, Guannan Wang, Yuxin Li*. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling. BMC Bioinformatics. 2013,14(1):41. 22.Cong Fan, Yanxin Huang*, Yongli Bao*, Luguo Sun, Yin Wu, Chunei Yu, Yu Zhang, Zhenbo Song, Lihua Zheng, Ying Sun, Gjuannan Wang, Yuxin Li*. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database. Int J Mol Sci. 2012 Dec 14;13(12):17185-209. 23.Yuyin Li, Yongli Bao*, Zhenbo Song, Luguo Sun, Ping Wu, Yu Zhang, Cong Fan, Yanxin Huang, Yin Wu, Chunlei Yu, Ying Sun, Lihua Zheng, Guannan Wang, and Yuxin Li*. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation. PLoS ONE. 2012, 7(5): e35030. Epub 2012 May 4. doi:10.1371/journal.pone.0035030. 科研项目 1.脐带间充质干细胞外泌体在银屑病治疗中的作用和机制研究 吉林省科技厅重点科技研发项目医药健康领域 2.系列抗病毒消毒产品 吉林省科技厅重点科技研发项目 3.miRNA在TSP50诱导的乳腺癌发生中的作用及机制研究 国家自然科学基金青年项目 4.miR-4709-3p在TSP50相关的乳腺癌转移中的调节作用和机制研究 吉林省科技厅青年科研基金 5.TSP50蛋白酶活性中心催化三联体在其促肿瘤发生中的作用及机制研究 吉林省科技厅青年科研基金 6.TSP50活性中心的催化三联体在细胞增殖和侵袭中的作用及机制研究 校内青年基金项目
其它信息
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