黄百渠

吉林省人民政府省政府参事省政府参事
吉林省人民政府参事参事

2017-11-10 吉林省科学技术奖自然科学奖一等奖
2010-12-31 教育部高等学校科学研究优秀成果奖自然科学一等奖
2005-03-21 吉林省高等教育省级教学成果特等奖
2002-12-21 吉林省科技进步二等奖
2001-05-01 中国高校科学技术二等奖
1991-12-01 吉林省教委科技进步奖(甲类)二等奖
1995-06-01 吉林省教委科技进步一等奖
1985-01-01 国家教委科技进步一等奖
1997-06-01 国家自然科学三等奖
1998-11-01 教育部科技进步二等奖

科技论文写作
2016级细胞生物学、遗传学硕士课
2020级细胞生物学博士
2016级细胞生物学、遗传学博士课
教授科研专题研讨

研究方向简介:

1.肿瘤细胞转移的表观遗传学
上皮细胞来源的恶性肿瘤细胞发生上皮-间质转化（EMT）后获得了较高的侵袭和迁移能力，浸润周围组织并进入循环系统，经过间质-上皮转化（MET）后在远端器官形成新的转移灶。上皮-间质转化的可塑性表明表观遗传修饰在此过程中发挥着重要作用。课题组主要研究调控恶性肿瘤细胞发生EMT过程的分子表观遗传学机制，并致力于开发基于调控EMT过程关键表观修饰因子为新靶标的诊断方法及药物。

2.细胞和生物体衰老的表观遗传学
细胞衰老相关异染色质凝集（SAHF）现象的发现表明染色质重塑与细胞衰老密切相关。研究表观遗传修饰及其介导的染色质结构改变在细胞衰老及SAHF中的作用及机制，将为更好地阐明表观遗传修饰与细胞衰老的关系提供重要的基础资料，同时对于阐明细胞衰老相关疾病（如儿童早衰症HGPS等）的发病机理具有重要的理论指导价值。同时，利用经典模式生物秀丽线虫（C.elegans），研究表观修饰因子调控衰老相关信号通路的分子机制，以及在生物体衰老过程中各种表观修饰间的相互作用关系。

3.抗肿瘤表观修饰药物
特异性的表观遗传修饰酶抑制剂（甲基转移酶抑制剂和组蛋白去乙酰化酶抑制剂）能够逆转特定基因的活性和修复异常细胞周期进程。以在肿瘤转移进程中异常高表达的表观修饰酶为靶标，筛选新型表观修饰酶抑制剂，以期开发新型抗肿瘤药物。


近年发表的主要论文：


2016：

The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer. Cell Death and Differentiation, 2016, Oct 7. doi: 10.1038/cdd.2016.95. (Epub ahead of print) (SCI, IF=8.22)

Androgen and AR Contribute to Breast Cancer Carcinogenesis and Metastasis: An Insight of Mechanisms. 2016, Oncogene, (in press) (SCI, IF=7.93)

Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer. 2016, Breast Cancer Res PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Scientific Reports, 6:19874, 27 January 2016, DOI:10.1038/srep19874 (SCI, IF=5.578)

Suppression of RAD21 induces senescence of MDA-MB-231 human breast cancer cells through RB1 pathway activation via c-Myc downregulation. J. Cellular Biochemistry, 2016, Jun; 117(6):1359-69. doi: 10.1002/jcb.25426 (SCI, IF=3.263)


2015：

SHON, a novel secreted protein, regulates epithelial mesenchymal transition through transforming growth factor (TGF)-β signaling in human breast cancer cells. 2015, International J. Cancer 136, 1285-1295 (SCI, IF=5.085)

JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation ofrative role of HMGA2 in induction of apoptosis through Caspase-2 in primary human fibroblast cells. Bioscience Reports, 2015 Jan 14;35(1). pii: e00169. doi: 10.1042/BSR20140112 (SCI, IF=2.637)


2014：

Protein arginine methyltransferase 7 (PRMT7) induces the epithelial-to-mesenchymal transition and promotes breast cancer metastasis. 2014, Cancer Research 74(19):5656-5667 (SCI, IF=9.284)

LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and met
CDK5 is essential for TGF-b1-induced epithelial-mesenchymal transition and breast cancer progression. Scientific Reports, 2013, Oct 14; 3:2932. doi: 10.1038/srep02932 (SCI, IF=5.078)

Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumor cells. 2013, FEBS J., 280(18):4625-4639 (SCI, IF=3.986)

SHON Is a Novel Estrogen-Regulated Oncogene in Mammary Carcinoma That Predicts Patient Response to Endocrine Therapy. 2013, Cancer Research, 73(23):6951-6962 (SCI, IF=9.284)


2012：

SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. 2012, Cancer Research 72(17):4597-4608 (SCI, IF=8.65)

ATRA inhibits the proliferation of DU145 prostate cancer cel
FOXC1, a target of polycomb, inhibits metastasis of breast cancer cells. 2012, Breasssociated with Cyclin B1-dependent survivin degradation and apoptosis in LNCap cells.2012, Journal of Cellular Biochemistry, 113(7):2375-2382 (SCI, IF= 3.062)

Suppression of PRMT6-mediated arginine methylation of p16 protein potentiates its ability to arrest A549 cell proliferation. 2012, The International Journal of Biochemistry & Cell Biology, 44(12):2333-2341 (SCI, IF= 4.152)


2011：

Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung caner cells. 2011, Biochemical Journal 433(2):333-343 (SCI, IF=5.016)

DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. 2011, International Journal of Cancer 128(3):551-561 (SCI, IF=5.444)

Discovery of polyoxometalate-based HDAC inhibitors with profound anticancer activit)

NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS ONE 6(7): e22666 (July, 28th, 2011) (SCI, IF=4.092)


专利：

发明专利名称：重组人血管抑素K1-3的制备工艺及其制品在肿瘤治疗药物中的应用；
完成人：李玉新 乌垠 鲍永利 王秀红 孟祥颖 易静雯 黄百渠 郝水；
专利证书号：ZL200510016592.7
授权公告日：2009-09-09

发明专利名称：组蛋白去乙酰化酶抑制剂有机锡多酸化合物及其制备方法
完成人：刘术侠  黄百渠 张春丹 陆军 王春玲 陈玉丽 
专利证书号： ZL 2007 1 0056078.5
授权日期：2011-09-07